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Titolo:
An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration
Autore:
Cassarino, DS; Bennett, JP;
Indirizzi:
Univ Virginia, Hlth Sci Ctr, Dept Neurol, Charlottesville, VA 22908 USA Univ Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA Univ22908inia, Hlth Sci Ctr, Med Sci Training Program, Charlottesville, VAUniv Virginia Charlottesville VA USA 22908 g Program, Charlottesville, VA Univ08irginia, Hlth Sci Ctr, Grad Program Neurosci, Charlottesville, VA 229 Univ Virginia Charlottesville VA USA 22908 rosci, Charlottesville, VA 229 Univ Virginia, Hlth Sci Ctr, Ctr Study Neurodegenerat Dis, Charlottesville, Univ Virginia Charlottesville VA USA 22908 egenerat Dis, Charlottesville, UnivSAirginia, Hlth Sci Ctr, Dept Psychiat Med, Charlottesville, VA 22908 U Univ Virginia Charlottesville VA USA 22908 d, Charlottesville, VA 22908 U Univ Virginia, Hlth Sci Ctr, Dept Pharmacol, Charlottesville, VA 22908 USAUniv Virginia Charlottesville VA USA 22908 Charlottesville, VA 22908 USA
Titolo Testata:
BRAIN RESEARCH REVIEWS
fascicolo: 1, volume: 29, anno: 1999,
pagine: 1 - 25
SICI:
0165-0173(199901)29:1<1:AEOTRO>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMYOTROPHIC-LATERAL-SCLEROSIS; PERMEABILITY TRANSITION PORE; SUPEROXIDE-DISMUTASE ACTIVITY; GLUTATHIONE-PEROXIDASE ACTIVITY; RAT-LIVER MITOCHONDRIA; ANTIOXIDANT ENZYME-ACTIVITY; ELECTRON-TRANSPORT CHAIN; CENTRAL-NERVOUS-SYSTEM; MOTOR-NEURON DISEASE; IDIOPATHIC PARKINSONS-DISEASE;
Keywords:
Alzheimer's disease; Parkinson's disease; ALS; mitochondria; mitochondrial mutation; oxidative stress; cyclosporin A; mitochondrial permeability transition pore; apoptosis;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
276
Recensione:
Indirizzi per estratti:
Indirizzo: Bennett, JP Univ8Virginia, Hlth Sci Ctr, Dept Neurol, Box 394, Charlottesville, VA 2290 Univ Virginia Box 394 Charlottesville VA USA 22908 le, VA 2290
Citazione:
D.S. Cassarino e J.P. Bennett, "An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration", BRAIN RES R, 29(1), 1999, pp. 1-25

Abstract

There is mounting evidence for mitochondrial involvement in neurodegenerative diseases including Alzheimer's and Parkinson's disease and amyotrophic lateral sclerosis. Mitochondrial DNA mutations, whether inherited or acquired, lead to impaired electron transport chain (ETC) functioning. Impaired electron transport, in turn, leads to decreased ATP production, formation ofdamaging free-radicals, and altered calcium handling. These toxic consequences of ETC dysfunction lead to further mitochondrial damage including oxidation of mitochondrial DNA, proteins, and lipids, and opening of the mitochondrial permeability transition pore, an event linked to cell death in numerous model systems. Although protective nuclear responses such as antioxidant enzymes and bcl-2 may be induced to combat these pathological changes, such a vicious cycle of increasing oxidative damage may insidiously damage neurons over a period of years, eventually leading to neuronal cell death. This hypothesis, a synthesis of the mitochondrial mutations and oxidative stress hypotheses of neurodegeneration, is readily tested experimentally, andclearly points out many potential therapeutic targets for preventing or ameliorating these diseases. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/20 alle ore 12:22:06