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Titolo:
Sustained attention performance in rats with intracortical infusions of 192 IgG-saporin-induced cortical cholinergic deafferentation: Effects of physostigmine and FG 7142
Autore:
McGaughy, J; Sarter, M;
Indirizzi:
Ohio State Univ, Dept Psychol, Columbus, OH 43210 USA Ohio State Univ Columbus OH USA 43210 ept Psychol, Columbus, OH 43210 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 6, volume: 112, anno: 1998,
pagine: 1519 - 1525
SICI:
0735-7044(199812)112:6<1519:SAPIRW>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
BENZODIAZEPINE RECEPTOR LIGANDS; BASAL FOREBRAIN; BEHAVIORAL VIGILANCE; COGNITIVE FUNCTIONS; STIMULATION; LESIONS; ACETYLCHOLINE; FG-7142; ANTAGONIST; EFFLUX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Sarter, M OhioHState Univ, Dept Psychol, 1885 Neil Ave,27 Townshend Hall, Columbus, O Ohio State Univ 1885 Neil Ave,27 Townshend Hall Columbus OH USA43210
Citazione:
J. McGaughy e M. Sarter, "Sustained attention performance in rats with intracortical infusions of 192 IgG-saporin-induced cortical cholinergic deafferentation: Effects of physostigmine and FG 7142", BEHAV NEURO, 112(6), 1998, pp. 1519-1525

Abstract

Rats with extensive lesions of cortical cholinergic afferents as a result of infusions of 192 IgG-saporin into the basal forebrain show persistent impairments in sustained attention performance (J. McGaughy, T. Kaiser, & M. Sarter, 1996). However, the administration of neither the cholinesterase inhibitor physostigmine nor the benzodiazepine receptor partial inverse agonist FG 7142 attenuated the lesion-induced impairments in performance. The present study demonstrated that less extensive cortical cholinergic deafferentation, produced by intracortical infusions of a relatively small concentration of 192 IgG-saporin, resulted in a significant impairment in sustained attention. However, the administration of neither physostigmine (0.01-0.1 mg/kg) nor FG 7142 (0.1-1.0 mg/kg) benefited the performance of the animals. Because neither compound selectively augments performance-associated increases in acetylcholine release from residual neurons, beneficial effects on cortical cholinegic deafferentation-based impairments in attention may remain limited.

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Documento generato il 20/01/20 alle ore 10:16:27