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Titolo:
Norepinephrine release in the amygdala after systemic injection of epinephrine or escapable footshock: Contribution of the nucleus of the solitary tract
Autore:
Williams, CL; Men, D; Clayton, EC; Gold, PE;
Indirizzi:
Univ Virginia, Dept Psychol, Charlottesville, VA 22903 USA Univ Virginia Charlottesville VA USA 22903 Charlottesville, VA 22903 USA
Titolo Testata:
BEHAVIORAL NEUROSCIENCE
fascicolo: 6, volume: 112, anno: 1998,
pagine: 1414 - 1422
SICI:
0735-7044(199812)112:6<1414:NRITAA>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
VAGUS NERVE; BRAIN-STEM; PERIPHERAL EPINEPHRINE; RETENTION PERFORMANCE; BASOLATERAL COMPLEX; VAGAL INNERVATION; MEMORY-SYSTEMS; ADRENAL-GLAND; RAT AMYGDALA; GLUCOSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Williams, CL Univ Virginia, Dept Psychol, 102 Gilmer Hall, Charlottesville, VA 22903 USA Univ Virginia 102 Gilmer Hall Charlottesville VA USA 22903 SA
Citazione:
C.L. Williams et al., "Norepinephrine release in the amygdala after systemic injection of epinephrine or escapable footshock: Contribution of the nucleus of the solitary tract", BEHAV NEURO, 112(6), 1998, pp. 1414-1422

Abstract

Several findings based largely on lesions and drug manipulations within the amygdala suggest that norepinephrine (NE) systems in the amygdala contribute to enhancement of memory processes by epinephrine (EPI). However, no studies to date have directly measured changes in the release of NE in the amygdala after EPI injection. In Experiment 1, in vivo microdialysis was usedto assess amygdala NE release after systemic injection of saline, EPI (0.1or 0.3 mg/kg), and administration of an escapable footshock (0.8 mA, 1 s). Both doses of EPI produced a significant elevation in NE release that persisted for up to 60 min. In Experiment 2, the local anesthetic lidocaine (2%) was infused (0.5 mu l) into the nucleus of the solitary tract (NTS) immediately before injection of 0.3 mg/kg EPI. The EPI-induced elevation in amygdala NE release observed in Experiment 1 was attenuated by inactivation of the NTS. These findings indicate that systemic injection of EPI increases release of NE in the amygdala and suggest that the effects are mediated in part by activation of brainstem neurons in the NTS that project to the amygdala.

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Documento generato il 13/07/20 alle ore 17:07:08