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Titolo:
Stem cell technology for basic science and clinical applications
Autore:
Shihabuddin, LS; Ray, J; Gage, FH;
Indirizzi:
Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
ARCHIVES OF NEUROLOGY
fascicolo: 1, volume: 56, anno: 1999,
pagine: 29 - 32
SICI:
0003-9942(199901)56:1<29:SCTFBS>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; TRANSPLANTATION; DISEASE; MODEL; CNS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Shihabuddin, LS Salk037st Biol Studies, Genet Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92 Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
L.S. Shihabuddin et al., "Stem cell technology for basic science and clinical applications", ARCH NEUROL, 56(1), 1999, pp. 29-32

Abstract

In the adult mammalian central nervous system (CNS), most of the mechanisms responsible for cell proliferation and migration are shut off; thus, the capacities for self-repair and cellular replacement are greatly diminished. Observations that cell division continues in some regions of the adult brain and some resulting cells become neurons prompted attempts to identify the progenitor cells responsible for both embryonic and postnatal neural developments. The term stem cells refers to a population of cells that is capable of extended self-renewal and the ability to generate multilineage (neurons and glia) cell types (Figure). The growing interest in the isolation andpropagation of stem cells and studying stem cell biology is driven by 2 goals. The first goal is to establish an in vitro system to ellucidate the fate pathways of individual neural progenitors. Such a system can be used to determine signaling molecules controlling the generation of specific neuralcell lineages and to dissect cellular mechanisms underlying the progressive processes of commitment, fate determination, and differentiation during neural development. The second goal is to use such cultured, well-characterized cells for therapeutic applications in the treatment of neurologic and neurodegenerative diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:15:49