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Titolo:
Isolated lung perfusion with cisplatin in a rat lung solitary tumor nodulemodel
Autore:
Li, TS; Sugi, K; Ueda, K; Nawata, K; Nawata, S; Esato, K;
Indirizzi:
Yamaguchi Univ, Sch Med, Dept Surg 1, Ube, Yamaguchi 7558505, Japan Yamaguchi Univ Ube Yamaguchi Japan 7558505 Ube, Yamaguchi 7558505, Japan
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 6A, volume: 18, anno: 1998,
pagine: 4171 - 4176
SICI:
0250-7005(199811/12)18:6A<4171:ILPWCI>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
PULMONARY METASTASES; SARCOMA; DOXORUBICIN; ESTABLISHMENT; CHEMOTHERAPY; SURVIVAL; FUDR;
Keywords:
cisplatin; isolated lung perfusion; pharmacokinetic; rat; solitary lung tumor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Sugi, K Yamaguchi Univ, Sch Med, Dept Surg 1, Kogushi 1144, Ube, Yamaguchi7558505, Yamaguchi Univ Kogushi 1144 Ube Yamaguchi Japan 7558505 i 7558505,
Citazione:
T.S. Li et al., "Isolated lung perfusion with cisplatin in a rat lung solitary tumor nodulemodel", ANTICANC R, 18(6A), 1998, pp. 4171-4176

Abstract

Background: The present study was conducted to evaluate the toxicity, pharmacokinetics and anti-tumor potency of isolated lung perfusion (ILP) with cisplatin in a visible lung tumor nodule model in rats. Materials and Methods: A solitary tumor nodule was established by the injection of Methylcholanthrene-induced sarcoma cells into the left lung. Thirty rats were randomized to undergo ILP with either 0.1, 0.25, or 0.5 mg/mL cisplatin and bufferedhespan (BHE), or with an intravenous injection of 1.0 or 25 mg cisplatin. Results: The highest dose of cisplatin tolerated by the rats was 0.1 mg/mL for perfusion. A much higher platinum concentration in the tumor, of 6.67 +/- 1.64 vs. 2.51 +/- 0.60 mu g/g tissue but a significantly lower concentration in the serum and kidneys, was achieved by perfusion compared to that achieved by intravenous injection. A significantly lower tumor weight and 20% complete treatment response was achieved in rats given cisplatin than in those given BHE perfusion at 43.9 +/- 11.6 vs. 226.3 +/- 44.6 mg. Conclusion: ILP with cisplatin achieved superior results to intravenous injection according to the levels of toxicity and pharmacokinetic analysis, and it was effective against a visible armor nodule model in rats.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 00:30:02