Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
p53 and bcl-2 expression in locally advanced squamous cell head-neck cancer treated with platinum based chemotherapy and radiotherapy
Autore:
Giatromanolaki, A; Koukourakis, M; Zaramboukas, T; Skordalaki, A; Arapantoni, P; Georgoulias, V; Fountzilas, G;
Indirizzi:
Univ Hosp Iraklion, Dept Radiat & Med Oncol, Iraklion 71110, Crete, GreeceUniv Hosp Iraklion Iraklion Crete Greece 71110 klion 71110, Crete, Greece Univ Hosp Iraklion, Canc Biol Lab, Iraklion 71110, Crete, Greece Univ HospIraklion Iraklion Crete Greece 71110 klion 71110, Crete, Greece AristotelianGreeceSalonika, AHEPA Hosp, Dept Med Oncol, GR-54006 Salonika,Aristotelian Univ Salonika Salonika Greece GR-54006 , GR-54006 Salonika, Aristotelianeceiv Salonika, AHEPA Hosp, Dept Pathol, GR-54006 Salonika, Gre Aristotelian Univ Salonika Salonika Greece GR-54006 -54006 Salonika, Gre Georgios Papanikolaou Hosp, Dept Pathol, Salonika, Greece Georgios Papanikolaou Hosp Salonika Greece ept Pathol, Salonika, Greece METAXA Canc Hosp, Dept Pathol, Pireus, Greece METAXA Canc Hosp Pireus Greece A Canc Hosp, Dept Pathol, Pireus, Greece
Titolo Testata:
ANTICANCER RESEARCH
fascicolo: 6B, volume: 18, anno: 1998,
pagine: 4685 - 4692
SICI:
0250-7005(199811/12)18:6B<4685:PABEIL>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCTION CHEMOTHERAPY; LUNG-CARCINOMA; RADIATION; TRIALS; TUMORS; OVEREXPRESSION; PREVENTION; APOPTOSIS; HYPOXIA; PROTEIN;
Keywords:
p53; bcl-2; head-neck cancer; radiotherapy; platinum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Giatromanolaki, A Tumourreecegiogenesis Res Grp, 18 Dimokratias Ave, Iraklion 71306, Crete, G Tumour & Angiogenesis Res Grp 18 Dimokratias Ave Iraklion Crete Greece 71306
Citazione:
A. Giatromanolaki et al., "p53 and bcl-2 expression in locally advanced squamous cell head-neck cancer treated with platinum based chemotherapy and radiotherapy", ANTICANC R, 18(6B), 1998, pp. 4685-4692

Abstract

Background: The role of apoptosis regulating oncoproteins in defining response to cytotoxic therapy remains poorly understood. Loss of wild type p53 function and bcl-2 protein overexpression are well known to inhibit the apoptotic pathway in in vitro studies. Methods: We immunohistochemically examined the nuclear accumulation of mutant p53 and the cytoplasmic overpressionof bcl-2 proteins in 76 patients with locally advanced inoperable squamouscell cancer of the head and neck area. Patients were reated with platinum based cheomtherapy and radiotherapy (37 with induction and 39 with concurrent chemotherapy). The median follow up period was 72 months. Results: Thirty-five (46%) cases were positive for p53 and 41 (54%) negative, whilst 19 (25%) and 57 (75%) cases were positive and negative for bcl-2 repsectively. A high percentage of bcl-2 positive cells was associated with a low incidence of nodal involvement. A statistically significant higher percentage of p53 postive cells was observed in the group of patients with complete disappearance of the disease as compared to the group with residual disease aftertreatment (p = 0.01). High percentage of p53 positive cells and concurrentchemoradiotherapy was associated with better local progression free survival (p = 0.05 and 0.02). In multivariate analysis, the type of prognostic variable for local relapse (p = 0.02) and overall survival (p = 0.03). Conclusion: The present study provides evidence that p53 nuclear accumulation maybe associated with better response to DNA damaging cytotoxic agents. The association of wild type p53 loss with decreased DNA repair enzyme activity is a possible explanation. Induction platinum based chemotherapy may contribute to the selection of clonogenic cells with a radioresistant phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 06:08:12