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Titolo:
Early detection of anthracycline-induced cardiotoxicity by radionuclide angiocardiography
Autore:
Suzuki, J; Yanagisawa, A; Shigeyama, T; Tsubota, J; Yasumura, T; Shimoyama, K; Ishikawa, K;
Indirizzi:
Kyorin Univ, Sch Med, Dept Internal Med 2, Tokyo 1818611, Japan Kyorin Univ Tokyo Japan 1818611 ept Internal Med 2, Tokyo 1818611, Japan
Titolo Testata:
ANGIOLOGY
fascicolo: 1, volume: 50, anno: 1999,
pagine: 37 - 45
SICI:
0003-3197(199901)50:1<37:EDOACB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTRICULAR DIASTOLIC FUNCTION; CONGESTIVE HEART-FAILURE; ACUTE MYOCARDIAL-INFARCTION; QT INTERVAL PROLONGATION; FLOW VELOCITY PATTERNS; ADRIAMYCIN CARDIOTOXICITY; DOXORUBICIN CARDIOTOXICITY; DOPPLER-ECHOCARDIOGRAPHY; EJECTION FRACTION; FILLING RATE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ishikawa, K KyorinJapan, Sch Med, Dept Internal Med 2, 6-20-2 Shinkawa, Tokyo 1818611, Kyorin Univ 6-20-2 Shinkawa Tokyo Japan 1818611 okyo 1818611,
Citazione:
J. Suzuki et al., "Early detection of anthracycline-induced cardiotoxicity by radionuclide angiocardiography", ANGIOLOGY, 50(1), 1999, pp. 37-45

Abstract

For the early detection of myocardial damage associated with anthracyclinetherapy, electrocardiography, echocardiography, and radionuclide angiocardiography were used to assess cardiac function in 37 patients receiving anthracyclines (ie, adriamycin and daunorubicin at a total dose of 100-2,030 mg/m(2)). None of the patients developed clinical congestive heart failure. There were no significant changes of electrocardiographic and echocardiographic parameters after anthracycline administration. The left ventricular ejection fraction did not change significantly on radionuclide angiocardiography. However, the 1/3 peak filling rate (PFR) corrected by the end-diastoliccount (EDC) (1/3 PFR/EDC) and the 1/3 filling fraction (1/3 FF), the indices of early diastolic function, showed a significant decrease. These findings suggest that the 1/3 PFR/EDC and 1/3 FF determined by radionuclide imaging are useful for detecting silent myocardial damage induced by anthracyclines.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 19:43:58