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Titolo:
Sevoflurane and the nervous system
Autore:
Schwender, D; End, H; Daunderer, M; Fiedermutz, M; Peter, K;
Indirizzi:
Univ Munich, Inst Anasthesiol, Munich, Germany Univ Munich Munich Germany iv Munich, Inst Anasthesiol, Munich, Germany
Titolo Testata:
ANAESTHESIST
, volume: 47, anno: 1998, supplemento:, 1
pagine: S37 - S42
SICI:
0003-2417(199811)47:<S37:SATNS>2.0.ZU;2-X
Fonte:
ISI
Lingua:
GER
Soggetto:
AUDITORY-EVOKED POTENTIALS; CEREBRAL BLOOD-FLOW; NITROUS-OXIDE; COGNITIVE FUNCTIONS; GENERAL-ANESTHESIA; PSYCHOMOTOR PERFORMANCE; METABOLIC-RATE; ISOFLURANE; DESFLURANE; RECOVERY;
Keywords:
anaesthetics, volatile; sevoflurane; central nervous system;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
59
Recensione:
Indirizzi per estratti:
Indirizzo: Schwender, D Univ Munich, Inst Anasthesiol, Klinikum Innenstadt, Nussbaumstr 20, D-80336 Univ Munich Nussbaumstr 20 Munich Germany D-80336 0, D-80336
Citazione:
D. Schwender et al., "Sevoflurane and the nervous system", ANAESTHESIS, 47, 1998, pp. S37-S42

Abstract

During sevoflurane anaesthesia cerebral blood flow is preserved or slightly decreased. Cerebral oxygen consumption is reduced to 50% under 1 MAC sevoflurane. Autoregulation of cerebral blood flow and responsiveness of cerebral blood flow to changes in Pa CO2 are widely preserved. Sevoflurane produces a dose dependent increase in intracranial pressure and a decrease in cerebrovascular resistance that can not be observed under hypocapnic conditions. Central stimulus processing, the electroencephalogram and sensory evokedpotentials are suppressed under sevoflurane in a dose dependent fashion. The electrophysiological data indicate that intraoperative awareness phenomena should be suppressed with sevoflurane 1.5-2.0 vol.%. Recovery of cognitive and psychomotor functions seems to be faster and more complete after sevoflurane than after isoflurane anaesthesia. In inducing seizure like EEG ormuscle activity, sevoflurane seems to be comparable with isoflurane. Thereis no limitation of sevoflurane use in patients with concomitant psychiatric or neurological diseases, and sevoflurane may be valuable addition in neurosurgery or carotid surgery.

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Documento generato il 26/01/20 alle ore 10:00:32