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Titolo:
Osmoregulatory control of renal sodium excretion after sodium loading in humans
Autore:
Andersen, LJ; Norsk, P; Johansen, LB; Christensen, F; Engstrom, T; Bie, P;
Indirizzi:
Univ Copenhagen, Panum Inst, Dept Med Physiol, DK-2200 Copenhagen, DenmarkUniv Copenhagen Copenhagen Denmark DK-2200 , DK-2200 Copenhagen, Denmark Rigshosp, Danish Aerosp Med Ctr Res, DK-2200 Copenhagen, Denmark RigshospCopenhagen Denmark DK-2200 Ctr Res, DK-2200 Copenhagen, Denmark
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 44, anno: 1998,
pagine: R1833 - R1842
SICI:
0363-6119(199812)44:6<R1833:OCORSE>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-PEPTIDE; ANGIOTENSIN-II; ARGININE VASOPRESSIN; WATER-DEPRIVATION; HYPERTONIC NACL; SALINE INFUSION; CONSCIOUS DOGS; HUMAN-PLASMA; ALDOSTERONE; DEHYDRATION;
Keywords:
hypertonic saline; isotonic saline; angiotensin II; urodilatin;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Andersen, LJ Univnhagen,agen, Panum Inst, Dept Med Physiol, 3C Blegdamsvej, DK-2200 Cope Univ Copenhagen 3C Blegdamsvej Copenhagen Denmark DK-2200 pe
Citazione:
L.J. Andersen et al., "Osmoregulatory control of renal sodium excretion after sodium loading in humans", AM J P-REG, 44(6), 1998, pp. R1833-R1842

Abstract

The hypothesis that renal sodium handling is controlled by changes in plasma sodium concentration was tested in seated volunteers. A standard salt load (3.08 mmol/kg body wt over 120 min) was administered as 0.9% saline (Isot) or as 5% saline (Hypr) after 4 days of constant sodium intake of 75 (LoNa(+)) or 300 mmol/day (HiNa(+)). Hypr increased plasma sodium by similar to4 mmol/l but increased plasma volume and central venous pressure significantly less than Isot irrespective of diet. After LoNa(+), Hypr induced a smaller increase in sodium excretion than Isot (48 +/- 8 vs. 110 +/- 17 mu mol/min). However, after HiNa(+) the corresponding natriureses were identical (135 +/- 33 vs. 139 +/- 39 mu mol/min), despite significant difference between the increases in central venous pressure. Decreases in plasma ANG II concentrations of 23-52% were inversely related to sodium excretion. Mean arterial pressure, plasma oxytocin and atrial natriuretic peptide concentrations, and urinary excretion rates of endothelin-1 and urodilatin remained unchanged. The results indicate that an increase in plasma sodium may contribute to the natriuresis of salt loading when salt intake is high, supporting the hypothesis that osmostimulated natriuresis is dependent on sodium balance in normal seated humans.

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Documento generato il 25/11/20 alle ore 04:50:09