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Titolo:
Afferent renal inputs to paraventricular nucleus vasopressin and oxytocin neurosecretory neurons
Autore:
Ciriello, J;
Indirizzi:
UnivaWestern Ontario, Hlth Sci Ctr, Dept Physiol, London, ON N6A 5C1, Canad Univ Western Ontario London ON Canada N6A 5C1 , London, ON N6A 5C1, Canad
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 6, volume: 44, anno: 1998,
pagine: R1745 - R1754
SICI:
0363-6119(199812)44:6<R1745:ARITPN>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
VENTROLATERAL MEDULLA; NERVE-STIMULATION; RENORENAL REFLEXES; SUBFORNICAL ORGAN; CONSCIOUS RATS; HEART-RATE; HYPERTENSION; ACTIVATION; KIDNEY; MECHANORECEPTORS;
Keywords:
renal mechanoreceptors; renal chemoreceptors; hypothalamus; vasopressin; oxytocin; arterial pressure control; cardiovascular regulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
50
Recensione:
Indirizzi per estratti:
Indirizzo: Ciriello, J UnivaWestern Ontario, Hlth Sci Ctr, Dept Physiol, London, ON N6A 5C1, Canad Univ Western Ontario London ON Canada N6A 5C1 N6A 5C1, Canad
Citazione:
J. Ciriello, "Afferent renal inputs to paraventricular nucleus vasopressin and oxytocin neurosecretory neurons", AM J P-REG, 44(6), 1998, pp. R1745-R1754

Abstract

Extracellular single-unit recording experiments were done in pentobarbitalsodium-anesthetized rats to investigate the effects of electrical stimulation of afferent renal nerves (ARN) and renal vein (RVO) or artery (RAO) occlusion on the discharge rate of putative arginine vasopressin (AVP) and oxytocin (Oxy) neurons in the paraventricular nucleus of the hypothalamus (PVH). PVH neurons antidromically activated by electrical stimulation of the neurohypophysis were classified as either AVP or Oxy secreting on the basis of their spontaneous discharge patterns and response to activation of arterial baroreceptors. Ninety-eight putative neurosecretory neurons in the PVH were tested for their response to electrical stimulation of ARN: 44 were classified as putative AVP and 54 as putative Oxy neurons. Of the 44 AVP neurons, 52% were excited, 7% were inhibited, and 41% were nonresponsive to ARN stimulation. Of the 54 Oxy neurons, 43% were excited, 6% inhibited, and 51%were not affected by ARN. An additional 45 neurosecretory neurons (29 AVP and 16 Oxy neurons) were tested for their responses to RVO and/or RAG. RVO inhibited 42% of the putative AVP neurons and 13% of the putative Oxy neurons. On the other hand, RAO excited 33% of the AVP and 9% of the Oxy neurons. No AVP or Oxy neurons were found to be excited by RVO or inhibited by RAG. These data indicate that sensory information originating in renal receptors alters the activity of AVP and Oxy neurons in the PVH and suggest that these renal receptors contribute to the hypothalamic control of AVP and Oxy release into the circulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 18:28:10