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Titolo:
Leptin deficiency enhances sensitivity to endotoxin-induced lethality
Autore:
Faggioni, R; Fantuzzi, G; Gabay, C; Moser, A; Dinarello, CA; Feingold, KR; Grunfeld, C;
Indirizzi:
Univancisco,an Francisco, Metab Sect 111F, Dept Vet Affairs Med Ctr, San Fr Univ Calif San Francisco San Francisco CA USA 94121 fairs Med Ctr, San Fr Univ Colorado, Hlth Sci Ctr, Div Infect Dis, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 r, Div Infect Dis, Denver, CO 80262 USA Univ Colorado, Hlth Sci Ctr, Div Rheumatol, Denver, CO 80262 USA Univ Colorado Denver CO USA 80262 tr, Div Rheumatol, Denver, CO 80262 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 45, anno: 1999,
pagine: R136 - R142
SICI:
0363-6119(199901)45:1<R136:LDESTE>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
OBESE GENE; DIABETIC MICE; OB PROTEIN; DB/DB MICE; OB/OB MICE; RECEPTOR; PROLIFERATION; SIGNAL; CELLS; IDENTIFICATION;
Keywords:
lipopolysaccharide; bacterial product; OB protein; leptin receptor; interleukin; tumor necrosis factor; macrophage inflammatory protein; cytokine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Grunfeld, C Univlement San Francisco, Metab Sect 111F, Dept Vet Affairs Med Ctr, 4150 C Univ Calif San Francisco 4150 Clement St San Francisco CA USA94121
Citazione:
R. Faggioni et al., "Leptin deficiency enhances sensitivity to endotoxin-induced lethality", AM J P-REG, 45(1), 1999, pp. R136-R142

Abstract

Leptin is induced by lipopolysacchande (LPS) and cytokines. We investigated the role of leptin in LPS-induced toxicity using leptin-deficient (ob/ob)and leptin receptor-deficient (db/db) mice. Sensitivity to LPS-induced mortality is significantly greater in ob/ob mice compared with their own lean littermates but not in db/db mice. LPS reduced serum glucose in both ob/ob and db/db mice but induced corticosterone only in db/db mice. Despite the very high basal levels of serum leptin in db/db mice, a twofold increase in serum leptin levels was observed after LPS in both db/db mice and their lean littermates. No differences were detected in LPS-induced serum levels of interleukin (IL)-1 beta, tumor necrosis factor, macrophage inflammatory protein-1 alpha, and interferon-gamma in ob/ob mice compared with their own littermates. In contrast, a blunted induction of IL-10 and IL-1 receptor antagonist (IL-1Ra) was observed in ob/ob mice compared with their littermates. In vitro, leptin induced IL-1Ra production and upregulated the IL-1Ra induction by LPS in macrophages. Moreover, treatment with leptin reversed the increased sensitivity to LPS-induced lethality found in ob/ob mice. These results suggest that leptin participates in the host response to inflammationby modulating the host immune and cytokine responses after LPS.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/03/20 alle ore 15:07:58