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Titolo:
Preoptic recess noradrenergic receptors control modification of baroreflexsensitivity by hypertonicity
Autore:
Bealer, SL;
Indirizzi:
Univ Tennessee, Ctr Hlth Sci, Dept Physiol, Memphis, TN 38163 USA Univ Tennessee Memphis TN USA 38163 , Dept Physiol, Memphis, TN 38163 USA
Titolo Testata:
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
fascicolo: 1, volume: 45, anno: 1999,
pagine: R44 - R51
SICI:
0363-6119(199901)45:1<R44:PRNRCM>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC CEREBROVENTRICULAR INFUSION; ELEVATES BLOOD-PRESSURE; HEART-RATE; SODIUM-CHLORIDE; CONSCIOUS RATS; DIETARY NA; RESPONSES; SALT; NOREPINEPHRINE; HYPOTHALAMUS;
Keywords:
norepinephrine; anteroventral third ventricle; sympathetic nerve activity; bradycardia; baroreceptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Bealer, SL Univ3Tennessee, Ctr Hlth Sci, Dept Physiol, 894 Union Ave, Memphis, TN 3816 Univ Tennessee 894 Union Ave Memphis TN USA 38163 phis, TN 3816
Citazione:
S.L. Bealer, "Preoptic recess noradrenergic receptors control modification of baroreflexsensitivity by hypertonicity", AM J P-REG, 45(1), 1999, pp. R44-R51

Abstract

These studies examined the effects of alpha(1)- and alpha(2)-adrenoreceptor blockade in the anteroventral portion of the third cerebral ventricle (AV3V) on modification of baroreflex-induced changes in heart rate and renal sympathetic nerve activity (RSNA) induced by hyperosmolality. Local administration of hypertonic artificial cerebrospinal fluid (aCSF) in the AV3V significantly increased baroreflex-induced bradycardia during intravenous phenylephrine but did not alter changes in RSNA during the presser response or alter tachycardia and neural responses evoked by decreased blood pressure. The enhanced cardiac response was not observed during simultaneous administration of phentolamine (alpha(1)- and alpha(2)-antagonist) or yohimbine (selective alpha(2)-antagonist) in the AV3V region. However, treatment with prazosin (alpha(1)-antagonist) did not alter the exaggerated cardiac response evoked by hypertonic aCSF to increased blood pressure. These data demonstrate that acute, local hypertonic stimulation in the AV3V region selectively enhances baroreflex-induced bradycardia by stimulation of alpha(2)-adrenergic receptors during acute plessor responses.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 08/07/20 alle ore 07:40:45