Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The presence and absence of histocompatibility antigens in HIV type 1 produced by autologous blood-derived macrophages and peripheral blood lymphoblasts
Autore:
Tsai, WP; Kung, HF; Nara, PL;
Indirizzi:
NCI, Frederick Canc Res & Dev Ctr, Lab Biochem Physiol, Frederick, MD 21702 NCI Frederick MD USA 21702 Ctr, Lab Biochem Physiol, Frederick, MD 21702 NCI,b,Offerick Canc Res & Dev Ctr, Vaccine Resistant Dis Sect, Directors La NCI Frederick MD USA 21702 Ctr, Vaccine Resistant Dis Sect, Directors La
Titolo Testata:
AIDS RESEARCH AND HUMAN RETROVIRUSES
fascicolo: 1, volume: 15, anno: 1999,
pagine: 33 - 41
SICI:
0889-2229(19990101)15:1<33:TPAAOH>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; CLASS-I MOLECULES; CYTOMEGALOVIRUS-INFECTED CELLS; HLA CLASS-II; T-CELL; ENDOPLASMIC-RETICULUM; MEMBRANE-PROTEINS; DOWN-REGULATION; ADHESION RECEPTORS; VIRAL INFECTIVITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
78
Recensione:
Indirizzi per estratti:
Indirizzo: Tsai, WP NCI, Basic Res Lab, 37 Convent Dr,Bldg 37,Rm 6A11, Bethesda, MD 20892 USA NCI 37 Convent Dr,Bldg 37,Rm 6A11 Bethesda MD USA 20892 20892 USA
Citazione:
W.P. Tsai et al., "The presence and absence of histocompatibility antigens in HIV type 1 produced by autologous blood-derived macrophages and peripheral blood lymphoblasts", AIDS RES H, 15(1), 1999, pp. 33-41

Abstract

Acquisition of cellular proteins by HIV-1 virions is known to alter the physiology of the virus in vitro, Reported studies of this aspect have been largely limited to transformed T cell lines. In this study, we investigated the incorporation of major histocompatibility antigens (HLAs) on a primary macrophage-tropic isolate, HIV-1(ADA), grown from autologous monocyte-derived macrophages (MDMs) and peripheral blood mononuclear cells (PBMCs), A virus precipitation assay (VPA) demonstrated that HIV-1(ADA) grown from PBMCs incorporated substantial amounts of HLA class I (alpha chain and beta(2)m) and DR antigens, comparable with a laboratory strain, HIV-1(MN), grown fromthe same host cells. HIV-1(ADA), however, grown from MDMs incorporated significantly lower amounts of HLAI and -II antigens despite the fact that theinfected MDMs were found to express significant amounts of HLA antigens. The lack of incorporation of these important immunomodulatory cell surface proteins may be yet another unique characteristic of macrophage-tropic isolates and suggests a possible role in their biology and or immunology.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 03:28:08