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Titolo:
Antibody response to the N and C-terminal regions of the Plasmodium vivax Merozoite Surface Protein 1 in individuals living in an area of exclusive transmission of P-vivax malaria in the north of Brazil
Autore:
Soares, IS; Oliveira, SG; Souza, JM; Rodrigues, MM;
Indirizzi:
Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Univ Fed Sao Paulo Sao Paulo Brazil BR-04023062 BCol Imunol & Parasitol, Fedilniv Para, Ctr Ciencias Biol, Dept Patol, BR-66075900 Belem, Para, Braz Fed Univ Para Belem Para Brazil BR-66075900 BC-66075900 Belem, Para, Braz Inst Evandro Chagas, BR-66090000 Belem, Para, Brazil Inst Evandro Chagas Belem Para Brazil BR-66090000 BC0 Belem, Para, Brazil
Titolo Testata:
ACTA TROPICA
fascicolo: 1, volume: 72, anno: 1999,
pagine: 13 - 24
SICI:
0001-706X(19990115)72:1<13:ARTTNA>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNE-RESPONSE; FALCIPARUM; IMMUNIZATION; INFECTION; INVASION; FRAGMENT; BINDING; YOELII; MICE;
Keywords:
P-vivax; malaria; merozoite;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Rodrigues, MM Univ Fed Sao Paulo, Escola Paulista Med, Dept Microbiol Imunol & Parasitol, Univ Fed Sao Paulo Rua Botucatu 862 Sao Paulo Brazil BR-04023062 BC
Citazione:
I.S. Soares et al., "Antibody response to the N and C-terminal regions of the Plasmodium vivax Merozoite Surface Protein 1 in individuals living in an area of exclusive transmission of P-vivax malaria in the north of Brazil", ACT TROP, 72(1), 1999, pp. 13-24

Abstract

Recently, we found that a recombinant protein based on the 19 kDa C-terminal region of the Plasmodium vivax Merozoite Surface Protein 1 (PvMSP1(19)) was recognized by a large proportion of individuals naturally infected. Thepresent study was designed to determine the prevalence of antibody to PvMSP1(19) in individuals from the village of Cotijuba, northern Brazil, where only P. vivax transmission occurs. Immuno-epidemiological studies on the prevalence of antibody to the C-terminus of PvMSP1 are of particular importance as this region of MSP1 is bring intensively studied as a prime candidatefor development of a vaccine against malaria. We evaluated the antibody response to PvMSP1(19), and compared it to the N-terminal region of PvMSP1 and to blood stage antigens. The total frequencies of individuals with IgG toblood stages, PvMSP1(19) or the N-terminal region of PvMSP1 were 76.6, 42.3 and 29.8%, respectively. The frequency of responders to PvMSP1(19) did not increase with age. However, the frequency of responders to this recombinant protein was significantly higher (77.4%) in individuals with a recent (<6 months) history of malaria, when compared to subjects whose last malaria attack occurred more than 6 months before (43.9%), or to individuals without a past history of symptomatic malaria (6.25%). These results confirm earlier studies by demonstrating that the PvMSPI(19) is highly immunogenic in individuals recently exposed to P. vivax malaria. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 13:27:40