Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
High-voltage-activated calcium current and its modulation by dopamine D-4 and pituitary adenylate cyclase activating polypeptide receptors in cerebellar granule cells
Autore:
Yan-Ai, M;
Indirizzi:
Fudanhinav, Dept Physiol & Biophys, Liren Lab, Shanghai 200433, Peoples R C Fudan Univ Shanghai Peoples R China 200433 Shanghai 200433, Peoples R C
Titolo Testata:
ACTA PHARMACOLOGICA SINICA
fascicolo: 1, volume: 20, anno: 1999,
pagine: 3 - 9
SICI:
0253-9756(199901)20:1<3:HCCAIM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
38-AMINO ACID FORM; PACAP RECEPTORS; RAT CEREBELLUM; IN-SITU; D4 RECEPTORS; NEURONS; SCHIZOPHRENIA; EXPRESSION; APOPTOSIS; CLOZAPINE;
Keywords:
cerebellum; dopamine receptors; PACAP receptors; calcium channels; electrophysiology;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Yan-Ai, M Fudanhinav, Dept Physiol & Biophys, Liren Lab, Shanghai 200433, Peoples R C Fudan Univ Shanghai Peoples R China 200433 200433, Peoples R C
Citazione:
M. Yan-Ai, "High-voltage-activated calcium current and its modulation by dopamine D-4 and pituitary adenylate cyclase activating polypeptide receptors in cerebellar granule cells", ACT PHAR SI, 20(1), 1999, pp. 3-9

Abstract

Cerebellar granule cells were a good mold for electrophysiologic studies at the single neuron level. Two distinct types of high-voltage-activated Ca2 channels were present in cerebellar granule cells. These calcium channelschange their expression, gating, and pharmacological properties during development, suggesting that calcium channel must be related to the processes of granule cell maturation and excitability. Dopamine inhibited L-type calcium current by activating D-4 receptor, and this effect might involve another signaling system with the exception of cAMP system. The functional D-4 receptor discovered in cerebellum not only gave a possibility to find other antipsychotics, but also supported the existence of a dopaminergic system in the granule cell involving the D-4 receptor. Pituitary adenylate cyclase activating polypeptide (PACAP) could increase intracellular Ca2+ content byactivation of Ca2+ channel and mobilization of intracellular Ca2+ stores. The effects were also cAMP-independent. Activating Ca2+ currents might be an important and necessary role of PACAP as a neurotropic factor involved inthe control of multiplication, differentiation, and migration of granule cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:01:47