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Titolo:
Mismatch negativity and N2b attenuation as an indicator for dysfunction ofthe preattentive and controlled processing for deviance detection in schizophrenia: a topographic event-related potential study
Autore:
Kasai, K; Okazawa, K; Nakagome, K; Hiramatsu, KI; Hata, A; Fukuda, M; Honda, M; Miyauchi, M; Matsushita, M;
Indirizzi:
Univ Tokyo, Fac Med, Dept Neuropsychiat, Bunkyo Ku, Tokyo 113, Japan Univ Tokyo Tokyo Japan 113 pt Neuropsychiat, Bunkyo Ku, Tokyo 113, Japan Ishinomaki Senshu Univ, Dept Psychol, Kanagawa, Japan Ishinomaki Senshu Univ Kanagawa Japan iv, Dept Psychol, Kanagawa, Japan Teikyo Univ, Sch Med, Univ Hosp, Dept Psychiat, Kanagawa, Japan Teikyo Univ Kanagawa Japan d, Univ Hosp, Dept Psychiat, Kanagawa, Japan Univ Ryukyus, Fac Med, Dept Neuropsychiat, Okinawa, Japan Univ Ryukyus Okinawa Japan Fac Med, Dept Neuropsychiat, Okinawa, Japan Tokyo Metropolitan Matsuzawa Univ, Dept Psychiat, Tokyo, Japan Tokyo Metropolitan Matsuzawa Univ Tokyo Japan pt Psychiat, Tokyo, Japan Natlrs,r Neurol & Psychiat, Natl Ctr Hosp Mental Nervous & Muscular Disorde Natl Ctr Neurol & Psychiat Tokyo Japan ental Nervous & Muscular Disorde
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2, volume: 35, anno: 1999,
pagine: 141 - 156
SICI:
0920-9964(19990111)35:2<141:MNANAA>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
SELECTIVE-ATTENTION; STIMULUS DEVIANCE; AUDITORY-CORTEX; DEFICIT; DISCRIMINATION; ABNORMALITIES; IMPAIRMENT; RESPONSES; MEMORY; MODEL;
Keywords:
mismatch negativity; N2b; event-related potentials; selective attention task; topography; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Kasai, K Univ Tokyo, Fac Med, Dept Neuropsychiat, Bunkyo Ku, 7-3-1 Hongo, Tokyo 113, Univ Tokyo 7-3-1 Hongo Tokyo Japan 113 , 7-3-1 Hongo, Tokyo 113,
Citazione:
K. Kasai et al., "Mismatch negativity and N2b attenuation as an indicator for dysfunction ofthe preattentive and controlled processing for deviance detection in schizophrenia: a topographic event-related potential study", SCHIZOPHR R, 35(2), 1999, pp. 141-156

Abstract

The present study compares the amplitudes and topographic patterns of mismatch negativity (MMN) and N2b in schizophrenic patients and normal controls. Twenty-one schizophrenic outpatients and 19 normal volunteers participated in the study. Event-related potentials (ERPs) were recorded in a selective attention task. During the task, subjects were required to focus on one ear, counting deviant stimuli, those deviating in duration from a sequence of standard stimuli. MMN was significantly attenuated in the schizophrenics as compared with the normals in the frontocentral regions. In addition to MMN, the N2b amplitude was also reduced, which showed a significant correlation with the MMN amplitude in the schizophrenics. The late negativity elicited by the deviant stimuli in the unattended condition showed different topographical features between the groups. Whereas the normals showed a lateralized distribution with an ear-related asymmetry, similar to that of the N2b, the schizophrenics showed a frontal dominance, coinciding with the sustained negativity reported by Naatanen et al. (1982), which reflects the automatic preparation for detecting possible subsequent stimulus changes. The amplitude of the sustained negativity was significantly correlated with the performance level in the schizophrenics. The results indicated that although both preattentive and controlled processings are impaired, schizophrenic patients, presumably due to the deficient controlled processing, owe much to automatic processing in the deviant stimulus detection process. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 17/01/21 alle ore 18:16:33