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Titolo:
Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection
Autore:
Kreitschmann-Andermahr, I; Rosburg, T; Meier, T; Volz, HP; Nowak, H; Sauer, H;
Indirizzi:
Univ Jena, Dept Psychiat, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 ena, Dept Psychiat, D-07740 Jena, Germany Univ Jena, Biomagnet Ctr, D-07740 Jena, Germany Univ Jena Jena Germany D-07740 ena, Biomagnet Ctr, D-07740 Jena, Germany
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 2, volume: 35, anno: 1999,
pagine: 121 - 129
SICI:
0920-9964(19990111)35:2<121:ISPIMP>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
EVENT-RELATED POTENTIALS; EVOKED MAGNETIC-FIELDS; LEFT-HEMISPHERE; EYE-MOVEMENTS; NEGATIVITY; ABNORMALITIES; MEMORY; DYSFUNCTION; GENERATORS;
Keywords:
mismatch negativity; schizophrenia; magnetoencephalography; auditory information processing;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Kreitschmann-Andermahr, I Univ74echnol, Dept Neurosurg, Rhein Westfal TH Aachen, Pauwelsstr 30, D-520 Univ Technol Pauwelsstr 30 Aachen Germany D-52074
Citazione:
I. Kreitschmann-Andermahr et al., "Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection", SCHIZOPHR R, 35(2), 1999, pp. 121-129

Abstract

The generation of mismatch negativity (MMN) as a component of auditory evoked event-related brain potentials has been reported previously to be severely disturbed in patients with schizophrenia. In the present study, we extended these findings to magnetoencephalography and investigated the neuromagnetic mismatch field (MMNm) in 15 male schizophrenic inpatients as comparedto 16 healthy male volunteers. A standard tone of 1000 Hz and three different types of mismatch (1050-Hz tone, 5000-Hz tone, tone omission) were employed within the same paradigm, each mismatch occurring with a 10% pseudorandom probability. After correction for eye artifacts, the mean global field power of the mismatch reaction was calculated. Mismatch generation in patients with schizophrenia proved to be significantly impaired for all three conditions. This result confirms the theory of impaired auditory information processing in patients with schizophrenia at the level of the primary auditory cortex. Deficient generation of MMNm probably represents an impaired generation and/or faster decay of the sensory memory trace on the basis of disturbed sensory processing in male patients with schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 19/01/20 alle ore 09:09:19