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Titolo:
Imaging dopamine transmission in schizophrenia
Autore:
Laruelle, M;
Indirizzi:
ColumbiagUniv, Coll Phys & Surg, New York State Psychiat Inst, Brain Imagin Columbia Univ New York NY USA 10032 ork State Psychiat Inst, Brain Imagin
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 42, anno: 1998,
pagine: 211 - 221
SICI:
1125-0135(199809)42:3<211:IDTIS>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; C-11 N-METHYLSPIPERONE; H-3 RACLOPRIDE BINDING; RECEPTOR-BINDING; HUMAN-BRAIN; ENDOGENOUS DOPAMINE; D-4 RECEPTORS; D2 RECEPTORS; COMPUTERIZED-TOMOGRAPHY; PARKINSONS-DISEASE;
Keywords:
schizophrenia; dopamine; tomography, emission computed; tomography, emission computed, single photon;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
84
Recensione:
Indirizzi per estratti:
Indirizzo: Laruelle, M ColumbiagUniv, Coll Phys & Surg, New York State Psychiat Inst,Brain Imagin Columbia Univ 722 W 68th St,Unit 28 New York NY USA 10032 agin
Citazione:
M. Laruelle, "Imaging dopamine transmission in schizophrenia", Q J NUCL M, 42(3), 1998, pp. 211-221

Abstract

Over the last ten years, several positron emission tomography (PET) and single photon computerized tomography (SPECT) studies of the dopamine (DA) system in patients with schizophrenia were performed to test the hypothesis that DA hyperactivity is associated with this illness. In this paper, we reviewed the results of fifteen brain imaging studies comparing indices of DA function in drug naive or drug free patients with schizophrenia and healthycontrols: thirteen studies included measurement of DA D-2 receptors density, two studies compared amphetamine-induced DA release, and two studies measured DOPA decarboxylase activity, an enzyme involved in DA synthesis. We conducted a meta-analysis of the studies measuring D-2 receptor density parameters, under the assumption that all tracers labeled the same population of D-2 receptors. This analysis revealed that, compared to healthy controls,patients with schizophrenia present a significant but mild elevation of D-2 receptor density parameters and a significant larger variability of theseindices. We found no statistical evidence that studies performed with radiolabeled butyrophenones detected a larger increase in D-2 receptor density parameters than studies performed with other radioligands, such as benzamides. Studies of presynaptic activity revealed an increase in DA transmissionresponse to amphetamine challenge, and an increase in DOPA decarboxylase activity. Together, these data are compatible with both pre- and post-synaptic alterations of DA transmission in schizophrenia. Future studies should aim at a better characterization of these alterations, and at defining theirrole in the pathophysiology of the illness.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 10:31:27