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Titolo:
What are we measuring with PET?
Autore:
Morgan, AE; Brodie, JD; Dewey, SL;
Indirizzi:
Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 ab, Dept Chem, Upton, NY 11973 USA NYU, Sch Med, Dept Psychiat, New York, NY USA NYU New York NY USANYU, Sch Med, Dept Psychiat, New York, NY USA
Titolo Testata:
QUARTERLY JOURNAL OF NUCLEAR MEDICINE
fascicolo: 3, volume: 42, anno: 1998,
pagine: 151 - 157
SICI:
1125-0135(199809)42:3<151:WAWMWP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; BRAIN GLUCOSE-METABOLISM; ALZHEIMERS-DISEASE; MUSCARINIC RECEPTORS; CAUDATE-NUCLEUS; SENILE DEMENTIA; BINDING-SITES; DOPAMINE; SEROTONIN; SCHIZOPHRENIA;
Keywords:
tomography, emission computed; dopamine; serotonin; acetylcholine; GABA; neurotransmitters;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Dewey, SL Brookhaven Natl Lab, Dept Chem, Upton, NY 11973 USA Brookhaven Natl Lab Upton NY USA 11973 hem, Upton, NY 11973 USA
Citazione:
A.E. Morgan et al., "What are we measuring with PET?", Q J NUCL M, 42(3), 1998, pp. 151-157

Abstract

Positron emission tomography is a medical imaging technique that provides unique information concerning many biochemical mechanisms underlying normalphysiologic function. With respect to the central nervous system (CNS), selective radiolabeled compounds targeted at specific neurotransmitter receptor systems reveal information not only concerning receptor distribution andenzymatic activity but neurotransmitter concentrations as well. Recent advances in our understanding of these systems may be utilized to further understand changes in brain biochemistry that either result from or produce symptomatology associated with many CNS disease states. The ability to measureinteractions between neurotransmitter systems in the human brain may also add to our knowledge of drug side effects and disease progression. While many CNS diseases have been defined as "neurotransmitter-specific" in nature,scientific data now suggests that changes in multiple neurotransmitter systems are evident in the brains of patients suffering from these classicallydescribed diseases. PET is a powerful tool that can be used to examine many of these changes in the living human brain.

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Documento generato il 25/01/20 alle ore 03:32:18