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Titolo:
Possible role of neuropeptides in obsessive compulsive disorder
Autore:
McDougle, CJ; Barr, LC; Goodman, WK; Price, LH;
Indirizzi:
Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 ychiat, Indianapolis, IN 46202 USA Yale Univ, Sch Med, Dept Psychiat, New Haven, CT 06519 USA Yale Univ New Haven CT USA 06519 , Dept Psychiat, New Haven, CT 06519 USA Univ Florida, Coll Med, Dept Psychiat, Gainesville, FL 32608 USA Univ Florida Gainesville FL USA 32608 Psychiat, Gainesville, FL 32608 USA Brown Univ, Sch Med, Dept Psychiat & Human Behav, Providence, RI 02906 USABrown Univ Providence RI USA 02906 Human Behav, Providence, RI 02906 USA
Titolo Testata:
PSYCHONEUROENDOCRINOLOGY
fascicolo: 1, volume: 24, anno: 1999,
pagine: 1 - 24
SICI:
0306-4530(199901)24:1<1:PRONIO>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORTICOTROPIN-RELEASING-FACTOR; CEREBROSPINAL-FLUID NEUROCHEMISTRY; SEROTONIN REUPTAKE INHIBITORS; CLOMIPRAMINE-TREATED PATIENTS; EXCESSIVE GROOMING BEHAVIOR; BASAL GANGLIA DYSFUNCTION; LA-TOURETTE SYNDROME; NEUROHYPOPHYSEAL HORMONES; CSF SOMATOSTATIN; DOUBLE-BLIND;
Keywords:
obsessive compulsive disorder; neuropeptides; neurobiology; Tourette's syndrome; serotonin; dopamine;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
148
Recensione:
Indirizzi per estratti:
Indirizzo: McDougle, CJ Indiana Univ, Sch Med, Dept Psychiat, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 napolis, IN 46202 USA
Citazione:
C.J. McDougle et al., "Possible role of neuropeptides in obsessive compulsive disorder", PSYCHONEURO, 24(1), 1999, pp. 1-24

Abstract

The most consistent finding in clinical research of obsessive compulsive disorder (OCD) is the significant treatment advantage of potent serotonin uptake inhibitors (SUIs) over other classes of antidepressant and antianxietydrugs. Clinical neurobiological studies of OCD, however, have yielded limited and inconsistent evidence for significant fundamental abnormalities in monoamine systems including serotonin, norepinephrine and dopamine. Furthermore, one-third to one-half of OCD patients do not experience a clinically meaningful improvement with SUI treatment. Investigation beyond the monoamine systems may he necessary in order to more fully understand the pathophysiolog of obsessive-compulsive symptoms and develop improved treatments. Evidence from preclinical studies suggests that neuropeptides may have important influences on memory acquisition, maintenance and retrieval; grooming, maternal, sexual and aggressive behavior; fixed action patterns; and stereotyped behavior; these phenomena may relate to some features of OCD. In addition. extensive interactions have been identified in the brain between neuropeptidergic and monoaminergic systems, including co-localization among specific populations of neurons. The purpose of this review is to present the current knowledge of the role of neuropeptides in the clinical neurobiology of children, adolescents and adults with OCD focusing primarily on results from pharmacological challenge and cerebrospinal fluid studies. Where evidence exists. developmentally regulated differences in neuropeptide function between children and adolescents versus adults with OCD will be emphasized:these data are intended to underscore the potential importance of establishing the age of symptom onset (childhood versus adult) in individual patients with OCD participating in clinical neurobiological investigation. Likewise, where information is available, differences in measures of neuropeptides between patients with non-tic-related OCD versus tie-related OCD will be highlighted: these data will demonstrate the critical value of diagnostic precision, as these two particular subtypes of OCD may have different neurochemical underpinnings. (C) 1999 Elsevier Science Lid. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/04/20 alle ore 21:22:26