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Titolo:
Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults
Autore:
OLeary, DH; Polak, JF; Kronmal, RA; Manolio, TA; Burke, GL; Wolfson, SK;
Indirizzi:
Tufts New England Med Ctr, Dept Radiol, Boston, MA USA Tufts New England Med Ctr Boston MA USA Ctr, Dept Radiol, Boston, MA USA Brigham & Womens Hosp, Dept Radiol, Boston, MA 02115 USA Brigham & Womens Hosp Boston MA USA 02115 pt Radiol, Boston, MA 02115 USA Univ Washington, Dept Biostat, Seattle, WA 98195 USA Univ Washington Seattle WA USA 98195 Dept Biostat, Seattle, WA 98195 USA NHLBI, Div Epidemiol & Clin Applicat, Bethesda, MD 20892 USA NHLBI Bethesda MD USA 20892 emiol & Clin Applicat, Bethesda, MD 20892 USA WakeCForest Univ, Bowman Gray Sch Med, Dept Publ Hlth Sci, Winston Salem, N Wake Forest Univ Winston Salem NC USA 27103 bl Hlth Sci, Winston Salem, N Univ Pittsburgh, Dept Surg, Pittsburgh, PA USA Univ Pittsburgh PittsburghPA USA tsburgh, Dept Surg, Pittsburgh, PA USA
Titolo Testata:
NEW ENGLAND JOURNAL OF MEDICINE
fascicolo: 1, volume: 340, anno: 1999,
pagine: 14 - 22
SICI:
0028-4793(19990107)340:1<14:CIAMTA>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; CARDIOVASCULAR HEALTH; WALL THICKNESS; ATHEROSCLEROSIS RISK; SERUM-CHOLESTEROL; BLOOD-PRESSURE; PREVALENCE; ROTTERDAM; DETERMINANTS; ASSOCIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: O'Leary, DH CHS Coordinating Ctr, Century Sq,1501 4th Ave,Suite 2025, Seattle, WA 98101 CHS Coordinating Ctr Century Sq,1501 4th Ave,Suite 2025 Seattle WA USA 98101
Citazione:
D.H. O'Leary et al., "Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults", N ENG J MED, 340(1), 1999, pp. 14-22

Abstract

Background The combined thickness of the intima and media of the carotid artery is associated with the prevalence of cardiovascular disease. We studied the associations between the thickness of the carotid-artery intima and media and the incidence of new myocardial infarction or stroke in persons without clinical cardiovascular disease. Methods Noninvasive measurements of the intima and media of the common andinternal carotid artery were made with high-resolution ultrasonography in 5858 subjects 65 years of age or older. Cardiovascular events (new myocardial infarction or stroke) served as outcome variables in subjects without clinical cardiovascular disease (4476 subjects) over a median follow-up period of 6.2 years. Results The incidence of cardiovascular events correlated with measurements of carotid-artery intima-media thickness. The relative risk of myocardialinfarction or stroke increased with intima-media thickness (P<0.001). The relative risk of myocardial infarction or stroke (adjusted for age and sex)for the quintile with the highest thickness as compared with the lowest quintile was 3.87 (95 percent confidence interval, 2.72 to 5.51). The association between cardiovascular events and intima-media thickness remained significant after adjustment for traditional risk factors, showing increasing risks for each quintile of combined intima-media thickness, from the second quintile (relative risk, 1.54; 95 percent confidence interval, 1.04 to 2.28), to the third (relative risk, 1.84; 95 percent confidence interval, 1.26 to 2.67), fourth (relative risk, 2.01; 95 percent confidence interval, 1.38to 2.91), and fifth (relative risk, 3.15; 95 percent confidence interval, 2.19 to 4.52). The results of separate analyses of myocardial infarction and stroke paralleled those for the combined end point. Conclusions Increases in the thickness of the intima and media of the carotid artery, as measured noninvasively by ultrasonography, are directly associated with an increased risk of myocardial infarction and stroke in order adults without a history of cardiovascular disease. (N Engl J Med 1999;340:14-22. ) (C) 1999, Massachusetts Medical Society.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:01:03