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Titolo:
Modulating activity of human chorionic gonadotropin on growth and tumorigenesis of prostate cancer cells
Autore:
Chiao, JW; Turo, K; Yang, YM; Feldman, E; Traganos, F; Halicka, D; Kancherla, R; Fatora, SR; Ahmed, T; McMichael, J;
Indirizzi:
New York Med Coll, Dept Med, Valhalla, NY 10595 USA New York Med Coll Valhalla NY USA 10595 Dept Med, Valhalla, NY 10595 USA Milkhaus Lab Inc, Delanson, NY USA Milkhaus Lab Inc Delanson NY USAMilkhaus Lab Inc, Delanson, NY USA
Titolo Testata:
MOLECULAR UROLOGY
fascicolo: 2, volume: 2, anno: 1998,
pagine: 57 - 63
SICI:
1091-5362(199822)2:2<57:MAOHCG>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
KAPOSIS-SARCOMA; CARCINOMA CELLS; FLOW-CYTOMETRY; RECEPTOR GENE; HORMONE; EXPRESSION; LINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
18
Recensione:
Indirizzi per estratti:
Indirizzo: Chiao, JW New York Med Coll, Dept Med, Vosburgh 207, Valhalla, NY 10595 USA New York Med Coll Vosburgh 207 Valhalla NY USA 10595 Y 10595 USA
Citazione:
J.W. Chiao et al., "Modulating activity of human chorionic gonadotropin on growth and tumorigenesis of prostate cancer cells", MOL UROL, 2(2), 1998, pp. 57-63

Abstract

The hypothesis that human chorionic gonadotropin (hCG) is a nonandrogenic hormone regulating the proliferation and development of prostate cancer cells was investigated. The supplementation of human androgen-dependent LNCaP cancer cells with hCG caused growth reduction, apoptosis, and cell death. The hormone showed an identical dose- and time-dependent effect on cells grown in medium with or without steroids, suggesting an hCG mechanism independent of androgen. In androgen-independent prostatic cancer cell lines, hCG showed primarily a growth-modulating effect. It mediated a blocking of G(1) cells from entering into S phase. The analyses of hCG's effect on clonogenesis with androgen-independent JCA-1 cells revealed that hCG caused a drastic reduction in the number of tumor cell colonies and tumorigenesis. The demonstration of hCG receptors in the prostate complements these findings, indicating a direct functional role of hCG in this organ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 17:19:18