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Titolo:
PHARMACOLOGICAL ACTIVITY OF THE INTERDOMAIN SEGMENT BETWEEN METALLOPROTEINASE AND DISINTEGRIN DOMAINS
Autore:
KINI RM; ZHANG CY; TAN BKH;
Indirizzi:
NATL UNIV SINGAPORE,FAC SCI,BIOSCI CTR,LOWER KENT RIDGE RD SINGAPORE 0511 SINGAPORE NATL UNIV SINGAPORE,FAC MED,DEPT PHARMACOL SINGAPORE 0511 SINGAPORE
Titolo Testata:
Toxicon
fascicolo: 4, volume: 35, anno: 1997,
pagine: 529 - 535
SICI:
0041-0101(1997)35:4<529:PAOTIS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET-AGGREGATION INHIBITOR; HEMORRHAGIC METALLOPROTEINASES; COMMON PRECURSOR; VENOM PROTEINS; SNAKE-VENOMS; GENE FAMILY; SEQUENCE; BLOOD; VIPER; SUBUNITS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Kini et al., "PHARMACOLOGICAL ACTIVITY OF THE INTERDOMAIN SEGMENT BETWEEN METALLOPROTEINASE AND DISINTEGRIN DOMAINS", Toxicon, 35(4), 1997, pp. 529-535

Abstract

Metalloproteinases (haemorrhagic or non-haemorrhagic), disintegrins and most probably C-type lectin-related proteins are derived by the proteolysis of a common precursor protein. There is a short interdomain segment between the metalloproteinase and disintegrin domains which will be released into the venom. To determine whether this region of the molecule contributes to the biological role of the precursors or the products derived by the proteolysis of the precursors, we synthesized apeptide based on this short segment and examined its toxicity and biological activity. The synthetic peptide did not show any lethal toxicity, anticoagulant and antiplatelet effects. However, the peptide appeared to lower the blood pressure of normotensive rats upon infusion, but did not affect the blood levels of triglyceride, total cholesterol, high-density lipoproteins or low-density lipoproteins. The peptide, however, failed to exhibit any effect on spontaneously hypertensive ratsand hence may not have a potential as an antihypertensive agent. Based on these results, we conclude that this interdomain segment may not contribute significantly to the biological activity of precursor proteins. (C) 1997 Elsevier Science Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 09:17:51