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Titolo:
Genetics of ethanol-induced locomotor activation: detection of QTLs in a C57BL/6JxDBA/2JF(2) intercross
Autore:
Hitzemann, R; Cipp, L; Demarest, K; Mahjubi, E; McCaughran, J;
Indirizzi:
SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 ehav, Stony Brook, NY 11794 USA Vet Adm Med Ctr, Res Serv, Northport, NY 11768 USA Vet Adm Med Ctr Northport NY USA 11768 Res Serv, Northport, NY 11768 USA Vet Adm Med Ctr, Psychiat Serv, Northport, NY 11768 USA Vet Adm Med Ctr Northport NY USA 11768 hiat Serv, Northport, NY 11768 USA
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 12, volume: 9, anno: 1998,
pagine: 956 - 962
SICI:
0938-8990(199812)9:12<956:GOELAD>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
QUANTITATIVE-TRAIT-LOCI; INBRED MOUSE STRAINS; OPEN-FIELD ACTIVITY; SHORT-SLEEP MICE; COMPLEX TRAITS; LONG-SLEEP; ALCOHOL; LINKAGE; SENSITIVITY; PREFERENCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
48
Recensione:
Indirizzi per estratti:
Indirizzo: Hitzemann, R SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 rook, NY 11794 USA
Citazione:
R. Hitzemann et al., "Genetics of ethanol-induced locomotor activation: detection of QTLs in a C57BL/6JxDBA/2JF(2) intercross", MAMM GENOME, 9(12), 1998, pp. 956-962

Abstract

Moderate doses of ethanol (1-2 g/kg) markedly increase locomotor activity in some inbred mouse strains, for example, the DBA/2J (D2), but have relatively little effect in other strains, for example, the C57BL/6J (B6). In thepresent study, we conducted a genome-wide search in a B6D2 F-2 intercross (N = 925) for quantitative trait loci (QTLs) associated with the locomotor response. A QTL with a LOD score of 8.4 was detected on Chromosome (Chr) 2;this QTL accounted for 11.4% of the phenotypic variance and approximately 30% of the genetic variance. The QTL on Chr 2 is in the same general regionas QTLs previously described for ethanol preference/consumption (Rodriguezet al. Alcohol Clin Exp Res 19, 367, 1995; Melo et al. Nat Genet 13, 147, 1996; Phillips et al. Mamm Genome, in press), acute ethanol withdrawal (Buck et al. J. Neurosci 17, 3946, 1997) and nitrous oxide withdrawal severity (Belknap et al. Behav Genet 23, 213, 1993). A logical candidate gene in theregion of interest is the enzyme which synthesizes GABA, glutamic acid decarboxylase 1 (GadI).

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Documento generato il 30/03/20 alle ore 00:46:06