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Titolo:
Genomic screen for QTLs underlying alcohol consumption in the P and NP ratlines
Autore:
Bice, P; Foroud, T; Bo, RH; Castelluccio, P; Lumeng, L; Li, TK; Carr, LG;
Indirizzi:
Indiana Univ, Sch Med, Dept Med, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 pt Med, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Pharmacol, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 rmacol, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Mol & Med Genet, Indianapolis, IN 46202 USA Indiana Univ Indianapolis IN USA 46202 Genet, Indianapolis, IN 46202 USA Indiana Univ, Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USAIndiana Univ Indianapolis IN USA 46202 l Biol, Indianapolis, IN 46202 USA
Titolo Testata:
MAMMALIAN GENOME
fascicolo: 12, volume: 9, anno: 1998,
pagine: 949 - 955
SICI:
0938-8990(199812)9:12<949:GSFQUA>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROPEPTIDE-Y; PREFERRING P; MICE; PREFERENCE; DRINKING; MEN; IDENTIFICATION; SENSITIVITY; DENSITIES; RECEPTORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Carr, LG Indianat,niv, Sch Med, Dept Med, Med Res & Lib Bldg,Room 407,975 W Walnut S Indiana Univ Med Res & Lib Bldg,Room 407,975 W Walnut St Indianapolis IN USA 46202
Citazione:
P. Bice et al., "Genomic screen for QTLs underlying alcohol consumption in the P and NP ratlines", MAMM GENOME, 9(12), 1998, pp. 949-955

Abstract

Selective breeding for voluntary alcohol consumption was utilized to establish the alcohol-preferring (P) and alcohol-nonpreferring (UP) rat lines. Inbreeding was initiated after 30 generations of selection and, after 19 generations of inbreeding, 384 F-2 intercross progeny were created to identifyquantitative trait loci (QTLs) influencing alcohol consumption. We had reported previously a QTL on Chromosome (Chr) 4; additional markers genotyped on Chr 4 have increased the maximum lod score from 8.6 to 9.2. This QTL acts in an additive fashion and continues to account for approximately 11% of the phenotypic variability. The 95% confidence interval is 12.5 cM and includes the candidate gene, neuropeptide Y. Subsequent to the identification of the QTL on Chr 4, a genome scan was completed to identify additional QTLsinfluencing alcohol consumption. A lod score of 2.5 was obtained on Chr 3,syntenic to a region previously reported for alcohol preference in mice. Analysis of Chr 8 produced a lod score of 2.2 near the dopamine D2 and serotonin Ib receptors, which have been previously reported as candidate genes for alcohol preference. Evidence for linkage to alcohol consumption was not found on any other chromosome. It therefore appears likely that, in addition to the QTL on Chr 4, multiple loci of small to moderate effect, such as those on Chrs 3 and 8, underlie the difference in alcohol consumption in theP/NP lines.

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Documento generato il 02/07/20 alle ore 19:05:46