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Titolo:
Evaluation of serum uric acid changes in different forms of hepatic vascular inflow occlusion in human liver surgeries
Autore:
Kogure, K; Ishizaki, M; Nemoto, M; Kuwano, H; Tatemoto, K; Maruyama, Y; Ikarashi, Y; Makuuchi, M;
Indirizzi:
Gunma,Univ, Sch Med, Dept Surg 1, Inst Mol Regulat, Maebashi, Gumma 3718511 Gunma Univ Maebashi Gumma Japan 3718511 Regulat, Maebashi, Gumma 3718511 Gunmapaniv, Sch Med, Dept Neuropsychopharmacol, Maebashi, Gumma 3718511, Ja Gunma Univ Maebashi Gumma Japan 3718511 acol, Maebashi, Gumma 3718511, Ja Univ Tokyo, Grad Sch Med, Dept Surg 2, Tokyo, Japan Univ Tokyo Tokyo Japan v Tokyo, Grad Sch Med, Dept Surg 2, Tokyo, Japan
Titolo Testata:
LIFE SCIENCES
fascicolo: 5, volume: 64, anno: 1998,
pagine: 305 - 313
SICI:
0024-3205(199812)64:5<305:EOSUAC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL-ISCHEMIA; FREE-RADICALS; REPERFUSION; TRANSPLANTATION; INJURY; RAT; DAMAGE;
Keywords:
uric acid; hepatic vascular inflow occlusion; liver surgery;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
29
Recensione:
Indirizzi per estratti:
Indirizzo: Kogure, K Gunma,Univ, Sch Med, Dept Surg, 3-39-15 Showamachi, Maebashi, Gumma 3718511 Gunma Univ 3-39-15 Showamachi Maebashi Gumma Japan 3718511 18511
Citazione:
K. Kogure et al., "Evaluation of serum uric acid changes in different forms of hepatic vascular inflow occlusion in human liver surgeries", LIFE SCI, 64(5), 1998, pp. 305-313

Abstract

Uric acid values in serum have been analyzed as one of the markers to predict cellular damage due to ischemia reperfusion injury in the field of organ transplantation. The present study was conducted to confirm that uric acid values in serum could be an efficient marker of ischemic injury of liver parenchyma following hepatic vascular occlusion in human liver surgery. Thechanges in serum uric acid values were analyzed at fixed intervals during different liver surgeries. Significant increases in serum uric acid values were observed in patients who received the Pringle's maneuver in which hepatic vascular inflow was manipulated with a repetition of 15 min occlusion and 5 min perfusion, whereas almost no changes in uric acid values were found in both groups of patients who received the hemilobal occlusion of the Glisson's triad in which the right or left vessels were manipulated with a repetition of 30 min occlusion and 5 min perfusion and the "control method" in which the hepatic vessels of the lesion side were previously cut before liver resection. Uric acid values in serum increased in patients of Pringle's maneuver compared to those of the hemilobal occlusion of the Glisson's triad and the control method though these procedures were used in larger hepatectomies rather than Pringle's maneuver. The results indicated that serum uric acid values do not always reflect the severity of ischemia of the liver parenchyma but reflect intestinal congestion because marked intestinal congestion was observed in patients of Pringle's maneuver but not in patientsof the hemilobal occlusion of the Glisson's triad and the control method. The evaluation of the severity of the ischemic injury of the liver should be done with caution when uric acid is used as a marker in human liver surgery.

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Documento generato il 31/10/20 alle ore 21:27:59