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Titolo:
Spontaneous regression of hepatocellular carcinoma confirmed by surgical specimen: report of two eases and review of the literature
Autore:
Stoelben, E; Koch, M; Hanke, S; Lossnitzer, A; Gaertner, HJ; Schentke, KU; Bunk, A; Saeger, HD;
Indirizzi:
Tech Univ Dresden, Chirurg Klin, D-01307 Dresden, Germany Tech Univ Dresden Dresden Germany D-01307 Klin, D-01307 Dresden, Germany Techraxiv Dresden, Klinikum Carl Gustav Carus, Klin & Poliklin Viszeral Tho Tech Univ Dresden Dresden Germany D-8027 s, Klin & Poliklin Viszeral Tho Tech Univ Dresden, Klinikum Carl Gustav Carus, Inst Pathol, D-8027 Dresden, Tech Univ Dresden Dresden Germany D-8027 s, Inst Pathol, D-8027 Dresden, TechGermanyresden, Klinikum Carl Gustav Carus, Med Klin 1, D-8027 Dresden,Tech Univ Dresden Dresden Germany D-8027 us, Med Klin 1, D-8027 Dresden,
Titolo Testata:
LANGENBECKS ARCHIVES OF SURGERY
fascicolo: 6, volume: 383, anno: 1998,
pagine: 447 - 452
SICI:
1435-2443(199812)383:6<447:SROHCC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM ALPHA-FETOPROTEIN; NONCIRRHOTIC LIVER; NATURAL-HISTORY; PROGNOSIS; FEATURES; NECROSIS; CIRRHOSIS; HEPATOMA; CANCER;
Keywords:
hepatocellular carcinoma; spontaneous regression; spontaneous remission;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: Stoelben, E TechyUniv Dresden, Chirurg Klin, Fetscherstasse 74, D-01307 Dresden, German Tech Univ Dresden Fetscherstasse 74 Dresden Germany D-01307 n
Citazione:
E. Stoelben et al., "Spontaneous regression of hepatocellular carcinoma confirmed by surgical specimen: report of two eases and review of the literature", LANG ARCH S, 383(6), 1998, pp. 447-452

Abstract

Two cases with spontaneous regression of a histologically confirmed hepatocellular carcinoma (HCC) are presented. This rarely seen phenomenon of a spontaneous tumor involution is discussed and compared with the current literature. The clinical symptoms were very similar to that of a liver abscess. A 56-year-old male suffered from a multicentric, highly differentiated, trabecular HCC. First symptoms were epigastric pain, septic fever and arthritis. The tumor marker AFP was constantly normal and no hepatitis could be verified. A resection of the tumor was performed. In patient 2, a 74-year-old male, a multicentric, clear cell HCC was found. The patient had completely recovered from hepatitis type B and within the liver tissue no viruses could be identified. Clinical symptoms were mainly characterized by upper abdominal pain and septic fever. AFP was excessively elevated (3850 ng/ml) but returned to normal preoperatively. In both cases, the specimen showed a subtotal necrotic HCC with insignificant amounts of vital tumor cells. Neither patient had a liver cirrhosis macroscopically, however patient 2 had local periportal fibrosis histologically. After 24 and 41 months of follow-up, respectively, both patients are in good health and without evidence of tumor recurrence. Because of the common occurrence of vital tumor cells remainingwithin the necrosis as verified by histologic assessment of surgical specimens, we recommend surgical resection of HCC even when tumor regression is diagnosed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 11:19:25