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Titolo:
Magnetic resonance imaging of brain in people at high risk of developing schizophrenia
Autore:
Lawrie, SM; Whalley, H; Kestelman, JN; Abukmeil, SS; Byrne, M; Hodges, A; Rimmington, JE; Best, JJK; Owens, DGC; Johnstone, EC;
Indirizzi:
Univdlothian,h, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Mi Univ Edinburgh Edinburgh Midlothian Scotland EH10 5HF nburgh EH10 5HF, Mi Citylothian,inburgh, Magnet Resonance Imaging Unit, Edinburgh EH10 5SB, Mid City Hosp Edinburgh Edinburgh Midlothian Scotland EH10 5SB EH10 5SB, Mid
Titolo Testata:
LANCET
fascicolo: 9146, volume: 353, anno: 1999,
pagine: 30 - 33
SICI:
0140-6736(19990102)353:9146<30:MRIOBI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FIRST-EPISODE SCHIZOPHRENIA; ABNORMALITIES; TOMOGRAPHY; ILLNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Lawrie, SM Univdlothian,h, Royal Edinburgh Hosp, Dept Psychiat, Edinburgh EH10 5HF, Mi Univ Edinburgh Edinburgh Midlothian Scotland EH10 5HF 5HF, Mi
Citazione:
S.M. Lawrie et al., "Magnetic resonance imaging of brain in people at high risk of developing schizophrenia", LANCET, 353(9146), 1999, pp. 30-33

Abstract

Background Schizophrenia is a multifactorial disorder that is associated with disturbed cerebral development, Structural brain-imaging studies have consistently shown that the volumes of some parts of the brain, particularlythe mesial temporal lobes, are! smaller in patients with schizophrenia than in healthy people. Whether these abnormalities of brain structure predatethe onset of symptoms is not known. Methods 100 people at high risk of developing schizophrenia (two or more first-degree or second-degree relatives affected), 20 patients in their first episode of schizophrenia, and 30 healthy controls underwent magnetic resonance imaging of the brain. The volumes of regions of interest were measured by standard techniques. Findings Mean whole-brain volume was 1356 cm(3) (SD 178) in the first-episode group, 1347 cm(3) (122) in the high-risk group, and 1334 cm(3). (149) in the controls (p=0.8). The mean volume of the left amygdala-hippocampal complex (AHC) was lower in the first-episode group (4.3 cm(3) [0.6]) than in the high-risk group (4.6 cm(3) [0.6]), and in turn than in the controls (4.8 cm(3) [0.7]); these differences were significant (p<0.05) both for absolute volumes and values adjusted for brain volume and other confounders. The right AHC showed a similar pattern (absolute volumes 4.5 cm(3) [0.7], 4.8 cm(3) [0.6], 4.9 cm(3) [0.9]; respectively). Both thalamic nuclei were significantly smaller in the high-risk group than in the control group. Interpretation People at high risk of developing schizophrenia for geneticreasons have several structural brain abnormalities that are similar to those in patients with the disorder. lit-risk individuals with particularly small AHC or thalami are most likely to develop schizophrenia, this feature might assist in early detection and treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 13:07:34