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Titolo:
Central sympathoexcitatory actions of angiotensin II: Role of type 1 angiotensin II receptors
Autore:
Dibona, GF;
Indirizzi:
Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA Univ IowaIowa City IA USA 52242 pt Internal Med, Iowa City, IA 52242 USA Vet Adm Med Ctr, Iowa City, IA USA Vet Adm Med Ctr Iowa City IA USAVet Adm Med Ctr, Iowa City, IA USA
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
, volume: 10, anno: 1999, supplemento:, 11
pagine: S90 - S94
SICI:
1046-6673(199901)10:<S90:CSAOAI>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; SYMPATHETIC NERVOUS-SYSTEM; LONG-TERM CONTROL; BAROREFLEX CONTROL; HEART-FAILURE; RAT-BRAIN; ENDOGENOUS ANGIOTENSIN; ARTERIAL-PRESSURE; CHRONIC INFUSION; BLOOD-PRESSURE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
49
Recensione:
Indirizzi per estratti:
Indirizzo: Dibona, GF Univ Iowa, Coll Med, Dept Internal Med, 200 Hawkins Dr, Iowa City, IA 52242 Univ Iowa 200 Hawkins Dr Iowa City IA USA 52242 City, IA 52242
Citazione:
G.F. Dibona, "Central sympathoexcitatory actions of angiotensin II: Role of type 1 angiotensin II receptors", J AM S NEPH, 10, 1999, pp. S90-S94

Abstract

The role of the renin-angiotensin system in the control of sympathetic nerve activity is reviewed. Two general mechanisms are considered, one that involves the effects of circulating angiotensin II (AngII) on the central nervous system and a second that involves the central nervous system effects of AngII that originates within the central nervous system. The role of type1 AngII receptors in discrete brain sites that mediate the sympathoexcitatory actions of AngII of either circulating or central nervous system originis examined. AngII of circulating origin has ready access to the subfornical organ and area postrema, where it can bind to type 1 AngII receptors on neurons whose connections to the nucleus tractus solitarius and rostral ventrolateral medulla. result in sympathoexcitation. In the rostral ventrolateral medulla, angiotensin peptides of central nervous system origin, likely involving angiotensin species in addition to AngII and binding to receptorsother than type 1 or 2 AngII receptors, tonically support sympathetic nerve activity.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 12/07/20 alle ore 12:17:09