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Titolo:
Angiotensin II signal transduction in vascular smooth muscle: Pathways activated by specific tyrosine kinases
Autore:
Berk, BC;
Indirizzi:
Univ Rochester, Med Ctr, Cardiol Unit, Rochester, NY 14642 USA Univ Rochester Rochester NY USA 14642 rdiol Unit, Rochester, NY 14642 USA
Titolo Testata:
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
, volume: 10, anno: 1999, supplemento:, 11
pagine: S62 - S68
SICI:
1046-6673(199901)10:<S62:AISTIV>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
FOCAL ADHESION KINASE; CALCIUM-CHANNEL CURRENTS; N-TERMINAL KINASE; PROTEIN-KINASE; CELL-ADHESION; GROWTH-FACTOR; PHOSPHOLIPASE C-GAMMA-1; MESANGIAL CELLS; AT(1) RECEPTOR; SRC FAMILY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
64
Recensione:
Indirizzi per estratti:
Indirizzo: Berk, BC UnivNYochester, Med Ctr, Cardiol Unit, Box 679,601 Elmwood Ave, Rochester, Univ Rochester Box 679,601 Elmwood Ave Rochester NY USA 14642 er,
Citazione:
B.C. Berk, "Angiotensin II signal transduction in vascular smooth muscle: Pathways activated by specific tyrosine kinases", J AM S NEPH, 10, 1999, pp. S62-S68

Abstract

In this review, the signal events regulated by angiotensin II (AngII) in vascular smooth muscle are analyzed based on activation of specific tyrosinekinases. AngII has been shown to play a critical role in the pathogenesis of hypertension, inflammation, atherosclerosis, and congestive heart Failure. The expanding role of AngII indicates that multiple signal transduction pathways are likely to be activated in a tissue-specific manner. Although at least three AngII receptors have been characterized, it seems that the AngII type I receptor (ATIR) is physiologically most important since pharmacologic inhibitors of the ATIR block most AngII signal events and have beneficial effects on cardiovascular disease. The ATIR is a seven transmembrane-spanning G protein-coupled receptor that regulates intracellular signal events by activation of G(q) and G(i). However, many recent data indicate that activation of tyrosine kinases by several different mechanisms contributes to AngII effects in target tissues. Tyrosine kinases activated by AngII include c-Src, focal adhesion kinase (FAK), Pyk2 (CADTK), Janus kinases (JAK2 and TYK2), and the receptor tyrosine kinases Ax1, epidermal growth Factor, and platelet-derived growth factor. Finally, unknown tyrosine kinases may mediate tyrosine phosphorylation of paxillin, Shc, Raf, and phospholipase C-gamma after AngII stimulation. These AngII-regulated tyrosine kinases seem to be required for AngII effects such as vasoconstriction, proto-oncogene expression, and protein synthesis based on studies with tyrosine kinase inhibitors. Thus, understanding AngII-stimulated signaling events, especially those related to tyrosine kinase activity, may form the basis for the development of new therapies for cardiovascular diseases.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/07/20 alle ore 15:01:26