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Titolo:
Desipramine clearance in children and adolescents: Absence of effect of development and gender
Autore:
Cohen, LG; Biederman, J; Wilens, TE; Spencer, TJ; Mick, E; Faraone, SV; Prince, J; Flood, JG;
Indirizzi:
Massachusetts Gen Hosp, Dept Pharm, Boston, MA 02114 USA Massachusetts GenHosp Boston MA USA 02114 pt Pharm, Boston, MA 02114 USA Massachusetts Gen Hosp, Pediat Psychopharmacol Unit, Psychiat Serv, Boston, Massachusetts Gen Hosp Boston MA USA 02114 l Unit, Psychiat Serv, Boston, Massachusetts Gen Hosp, Chem Lab, Boston, MA 02114 USA Massachusetts Gen Hosp Boston MA USA 02114 Chem Lab, Boston, MA 02114 USA Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 Med, Dept Psychiat, Boston, MA 02115 USA Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA Harvard Univ Boston MA USA 02115 h Med, Dept Pathol, Boston, MA 02115 USA
Titolo Testata:
JOURNAL OF THE AMERICAN ACADEMY OF CHILD AND ADOLESCENT PSYCHIATRY
fascicolo: 1, volume: 38, anno: 1999,
pagine: 79 - 85
SICI:
0890-8567(199901)38:1<79:DCICAA>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEFICIT HYPERACTIVITY DISORDER; SPARTEINE OXIDATION PHENOTYPE; TRICYCLIC ANTI-DEPRESSANT; DOUBLE-BLIND; CLINICAL PHARMACOKINETICS; IMIPRAMINE DEMETHYLATION; TOURETTES-SYNDROME; DRUG DEVELOPMENT; INDUCED MANIA; IN-VIVO;
Keywords:
desipramine; pharmacokinetics; gender;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Citazioni:
67
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, LG Massachusetts4Gen Hosp, Dept Pharm, VBK BA 020,55 Fruit St, Boston, MA 0211 Massachusetts Gen Hosp VBK BA 020,55 Fruit St Boston MA USA 02114
Citazione:
L.G. Cohen et al., "Desipramine clearance in children and adolescents: Absence of effect of development and gender", J AM A CHIL, 38(1), 1999, pp. 79-85

Abstract

Objective: To examine the influence of development and gender on the pharmacokinetics of desipramine (DMI) in the pediatric population. Method: DMI pharmacokinetic parameters were calculated from 407 routinely drawn, dose- and weight-normalized serum concentrations in 173 youths receiving DMI (90 children, 83 adolescents; 29 were female, 144 were male). Results: Mean pharmacokinetic parameters for the entire population included dose (3.78 +/- 1.51 mg/kg), weight- and dose-normalized serum concentration (45.41 +/- 47.39[mu g/L]/[mg/kg]) and DMI clearance (0.68 +/-1.51 [L/kg]/hr). No between-group differences for children and adolescents were detected in dose (child,adolescent) (3.73 +/- 1.40 mg/kg, 3.83 +/- 1.68 mg/kg), weight- and dose-normalized serum concentrations (44.52 +/- 39.6 [mu g/L]/[mg/kg], 46.34 +/- 34.89 [mu g/L]/[mg/kg]; p = .62), and clearance (0.680 +/- 0.890 [L/kg]/hr,0.695 +/- 1.05 [L/kg]/hr; p = .103). No between-group gender differences were detected in dose (male, female) (3.83 +/- 1.55 mg, 3.39 +/- 1.84 mg), weight- and dose-normalized serum concentrations (45.15 +/-37.76 [mu g/L]/[mg/kg], 47.14 +/- 34.96 [mu g/L]/[mg/kg]; p = .720), and clearance (0.699 +/- 0.89 [L/kg]/hr, 0.606 +/- 0.535 [L/kg]/hr; p = .390). Conclusions: These results suggest that age and gender do not significantly influence DMI clearance or dose-normalized serum concentrations in the pediatric population.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 06:57:57