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Titolo:
Functionally dissociating aspects of event memory: The effects of combinedperirhinal and postrhinal cortex lesions on object and place memory in therat
Autore:
Bussey, TJ; Muir, JL; Aggleton, JP;
Indirizzi:
Cardiff Univ, Sch Psychol, Cardiff CF1 3YG, S Glam, Wales Cardiff Univ Cardiff S Glam Wales CF1 3YG Cardiff CF1 3YG, S Glam, Wales
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 19, anno: 1999,
pagine: 495 - 502
SICI:
0270-6474(19990101)19:1<495:FDAOEM>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FORNIX TRANSECTION; NEUROTOXIC LESIONS; PREFRONTAL CORTEX; TEMPORAL-LOBE; CORTICES; RECOGNITION; IMPAIRMENT; CINGULATE; ABLATION; MONKEYS;
Keywords:
episodic memory; event memory; spatial memory; object recognition; perirhinal cortex; postrhinal cortex; temporal lobe; rat;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Bussey, TJ NIMH, Neuropsychol Lab, NIH, Bldg 49,Room 1B80, Bethesda, MD 20892 USA NIMH Bldg 49,Room 1B80 Bethesda MD USA 20892 esda, MD 20892 USA
Citazione:
T.J. Bussey et al., "Functionally dissociating aspects of event memory: The effects of combinedperirhinal and postrhinal cortex lesions on object and place memory in therat", J NEUROSC, 19(1), 1999, pp. 495-502

Abstract

Reciprocal interactions between the hippocampus and the perirhinal and parahippocampal cortices form core components of a proposed temporal lobe memory system. For this reason, the involvement of the hippocampus in event memory is thought to depend on its connections with these cortical areas. Contrary to these predictions, we found that NMDA-induced lesions of the putative rat homologs of these cortical areas (perirhinal plus postrhinal cortices) did not impair performance on two allocentric spatial tasks highly sensitive to hippocampal dysfunction, Remarkably, for one of the tasks there wasevidence of a facilitation of performance. The same cortical lesions did, however, disrupt spontaneous object recognition and object discrimination reversal learning but spared initial acquisition of the discrimination. Thispattern of results reveals important dissociations between different aspects of memory within the temporal robe. Furthermore, it shows that the perirhinal-postrhinal cortex is not a necessary route for spatial information reaching the hippocampus and that object familiarity-novelty detection depends on different neural substrates than do other aspects of event memory.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 04:09:43