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Titolo:
Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2
Autore:
Demarest, K; McCaughran, J; Mahjubi, E; Cipp, L; Hitzemann, R;
Indirizzi:
SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 hiat, Stony Brook, NY 11794 USA SUNY Stony Brook, Dept Neurobiol & Behav, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 ehav, Stony Brook, NY 11794 USA Vet Adm Med Ctr, Res Serv, Northport, NY 11768 USA Vet Adm Med Ctr Northport NY USA 11768 Res Serv, Northport, NY 11768 USA Vet Adm Med Ctr, Psychiat Serv, Northport, NY 11768 USA Vet Adm Med Ctr Northport NY USA 11768 hiat Serv, Northport, NY 11768 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 19, anno: 1999,
pagine: 549 - 561
SICI:
0270-6474(19990115)19:2<549:IOAAER>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECOMBINANT-INBRED STRAINS; SYSTEM NEUROTENSIN MEASURES; ALCOHOL-RELATED BEHAVIORS; OPEN-FIELD ACTIVITY; SHORT-SLEEP MICE; GENETIC-ANALYSIS; COMPLEX TRAITS; LOCOMOTOR ACTIVATION; LONG-SLEEP; LINKAGE;
Keywords:
ethanol; mouse; genes; recombinant inbred; QTL; activity;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Hitzemann, R SUNY Stony Brook, Dept Psychiat, Stony Brook, NY 11794 USA SUNY Stony Brook Stony Brook NY USA 11794 rook, NY 11794 USA
Citazione:
K. Demarest et al., "Identification of an acute ethanol response quantitative trait locus on mouse chromosome 2", J NEUROSC, 19(2), 1999, pp. 549-561

Abstract

A two-stage strategy was used to identify and confirm quantitative trait loci (QTLs) associated with the changes in locomotor activity induced by a 1.5 gm/kg ethanol challenge. For stage 1, putative QTLs were identified by analysis of the strain means for 25 strains of the BXD recombinant inbred (RI) series (ma[es only). QTLs were identified on chromosomes 1, 2, 4, and 6. The activity response to chlordiazepoxide generated similar QTLs on chromosomes 2 and 6. None of the QTLs were similar to those generated from analysis of the saline response data. For stage 2, 900 male C57BL/6J (B6) x DBA/2J (D2) F-2 intercross animals were phenotyped for ethanol response, and thephenotypic extremes (those animals > and <1 SD from the mean) were identified. These extremes differed by >10,000 cm/15 min in their response to ethanol. The extreme progeny were used for a genome-wide scan both to confirm the putative Pi-generated QTLs and to detect new QTLs. The F-2 analysis generated no new QTLs with logarithm of the likelihood for linkage (LOD) scores>3. For RI-generated QTLs, only the QTL on chromosome 2 was confirmed (LOD= 5.3). The position of the peak LOD was estimated to be 47 cM with a 20 cM 1 LOD support interval; this QTL accounted for 6% of the phenotypic variance. The 1 LOD support interval overlaps with QTLs previously identified for alcohol preference and acute ethanol withdrawal (Melo et al., 1996; Buck et al., 1997; Phillips et al., 1999).

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Documento generato il 02/04/20 alle ore 02:50:07