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Titolo:
ATP released from astrocytes mediates glial calcium waves
Autore:
Guthrie, PB; Knappenberger, J; Segal, M; Bennett, MVL; Charles, AC; Kater, SB;
Indirizzi:
Univ Utah, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 Anat, Salt Lake City, UT 84132 USA Weizmann Inst Sci, Dept Neurobiol, IL-76100 Rehovot, Israel Weizmann Inst Sci Rehovot Israel IL-76100 biol, IL-76100 Rehovot, Israel Yeshiva Univ Albert Einstein Coll Med, Dept Neurosci, Bronx, NY 10461 USA Yeshiva Univ Albert Einstein Coll Med Bronx NY USA 10461 nx, NY 10461 USA Univ Calif Los Angeles, Sch Med, Dept Neurol, Los Angeles, CA 90024 USA Univ Calif Los Angeles Los Angeles CA USA 90024 Los Angeles, CA 90024 USA
Titolo Testata:
JOURNAL OF NEUROSCIENCE
fascicolo: 2, volume: 19, anno: 1999,
pagine: 520 - 528
SICI:
0270-6474(19990115)19:2<520:ARFAMG>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CULTURED RAT ASTROCYTES; DORSAL SPINAL-CORD; INTRACELLULAR CALCIUM; HUMAN-NEUTROPHILS; GAP-JUNCTIONS; ENDOTHELIAL-CELLS; EXTRACELLULAR ATP; PROPAGATION; RECEPTORS; NEURONS;
Keywords:
glia; astrocytes; calcium waves; ATP; extracellular signal; suramin; apyrase; purinergic; electrical stimulation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
65
Recensione:
Indirizzi per estratti:
Indirizzo: Kater, SB Univ Utah, Dept Neurobiol & Anat, Salt Lake City, UT 84132 USA Univ Utah Salt Lake City UT USA 84132 t Lake City, UT 84132 USA
Citazione:
P.B. Guthrie et al., "ATP released from astrocytes mediates glial calcium waves", J NEUROSC, 19(2), 1999, pp. 520-528

Abstract

Calcium waves represent a widespread form of intercellular communication. Although they have been thought for a long time to require gap junctions, we recently demonstrated that mouse cortical astrocytes use an extracellularmessenger for calcium wave propagation. The present experiments identify ATP as a major extracellular messenger in this system. Medium collected fromastrocyte cultures during (but not before) calcium wave stimulation contains ATP. The excitatory effects of medium samples and of ATP are blocked by purinergic receptor antagonists and by pretreatment with apyrase; these same purinergic receptor antagonists block propagation of electrically evoked calcium waves. ATP, applied at the concentration measured in medium samples, evokes responses that are qualitatively and quantitatively similar to those evoked by those medium samples. These data implicate ATP as an importanttransmitter between CNS astrocytes.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/07/20 alle ore 10:13:50