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Titolo:
Stimulation of human thalamus for pain relief: Possible modulatory circuits revealed by positron emission tomography
Autore:
Duncan, GH; Kupers, RC; Marchand, S; Villemure, JG; Gybels, JM; Bushnell, MC;
Indirizzi:
Univ Montreal, Ctr Rech Sci Neurol, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 ol, Montreal, PQ H3C 3J7, Canada Univ Montreal, Dept Stomatol, Fac Med Dent, Montreal, PQ H3C 3J7, Canada Univ Montreal Montreal PQ Canada H3C 3J7 nt, Montreal, PQ H3C 3J7, Canada McGill Univ, Fac Med, Dept Neurol & Neurosurg, Montreal, PQ, Canada McGillUniv Montreal PQ Canada Neurol & Neurosurg, Montreal, PQ, Canada McGill Univ, Fac Med, Dept Anesthesiol, Montreal, PQ, Canada McGill Univ Montreal PQ Canada d, Dept Anesthesiol, Montreal, PQ, Canada McGill Univ, Fac Dent, Montreal, PQ, Canada McGill Univ Montreal PQ Canada Gill Univ, Fac Dent, Montreal, PQ, Canada Univ Quebec Abitibi Temiscamingue, Rouyn Noranda, PQ, Canada Univ Quebec Abitibi Temiscamingue Rouyn Noranda PQ Canada da, PQ, Canada Univ Hosp Gasthuisberg, Dept Neurol & Neurosurg, B-3000 Louvain, Belgium Univ Hosp Gasthuisberg Louvain Belgium B-3000 g, B-3000 Louvain, Belgium
Titolo Testata:
JOURNAL OF NEUROPHYSIOLOGY
fascicolo: 6, volume: 80, anno: 1998,
pagine: 3326 - 3330
SICI:
0022-3077(199812)80:6<3326:SOHTFP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPINOTHALAMIC TRACT NEURONS; DEEP BRAIN-STIMULATION; ELECTRICAL-STIMULATION; NEUROPATHIC PAIN; COLD PAIN; NUCLEUS; INHIBITION; VIBRATION; ILLUSION; CORTEX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Duncan, GH Univ Montreal, Ctr Rech Sci Neurol, CP 6128,Succursale Ctr Ville, Montreal, Univ Montreal CP 6128,Succursale Ctr Ville Montreal PQ Canada H3C 3J7
Citazione:
G.H. Duncan et al., "Stimulation of human thalamus for pain relief: Possible modulatory circuits revealed by positron emission tomography", J NEUROPHYS, 80(6), 1998, pp. 3326-3330

Abstract

Stimulation of the somatosensory thalamus was used for more than 2 decadesto treat chronic pain in the human. However, despite clinical reports of successful results, little is known about the actual mechanisms mediating this form of stimulation-produced analgesia. To reveal possible neuronal pathways evoked by thalamic stimulation, we measured regional changes in cerebral blood flow (rCBF) in five patients who received successful long-term relief of chronic pain with somatosensory thalamic stimulation. Positron emission tomography during thalamic stimulation revealed significant activation of the thalamus in the region of the stimulating electrodes as well as activation of the insular cortex ipsilateral to the thalamic electrodes (contralateral to the patients' clinical pain). For these patients, thalamic stimulation also evoked paresthesiae that included thermal sensations in addition to tingling sensations. Results of this study indicate that in some casessomatosensory thalamic stimulation may activate a thalamocortical pain modulation circuit that involves thermal pathways. These results are consistent with other recent reports suggesting that activation of thermal pathways may contribute to modulation of nociceptive information.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 11:34:10