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Titolo:
Decreased plasma tryptophan associated with deep white matter lesions in elderly subjects
Autore:
Yao, H; Yuzuriha, T; Koga, H; Fukuda, K; Endo, K; Matsumoto, T; Kato, A; Uchino, A; Ezaki, T; Ibayashi, S; Uchimura, H; Fujishima, M;
Indirizzi:
Kyushuanniv, Fac Med, Dept Internal Med 2, Higashi Ku, Fukuoka 8128582, Jap Kyushu Univ Fukuoka Japan 8128582 ed 2, Higashi Ku, Fukuoka 8128582, Jap Hizen Natl Hosp, Ctr Emot & Behav Disorders, Saga, Japan Hizen Natl Hosp Saga Japan osp, Ctr Emot & Behav Disorders, Saga, Japan Saga Med Sch, Dept Radiol, Saga, Japan Saga Med Sch Saga JapanSaga Med Sch, Dept Radiol, Saga, Japan Saga Cent Hlth Ctr, Saga, Japan Saga Cent Hlth Ctr Saga JapanSaga Cent Hlth Ctr, Saga, Japan
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 1, volume: 66, anno: 1999,
pagine: 100 - 103
SICI:
0022-3050(199901)66:1<100:DPTAWD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
HYPERINTENSITIES; ABNORMALITIES; ROTTERDAM; DISORDERS; GLUTAMATE; DEMENTIA; PEOPLE;
Keywords:
magnetic resonance imaging; aging; amino acids;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Yao, H Kyushuokaiv, Fac Med, Dept Internal Med 2, Higashi Ku, Maidashi 3-1-1, Fuku Kyushu Univ Maidashi 3-1-1 Fukuoka Japan 8128582 dashi 3-1-1, Fuku
Citazione:
H. Yao et al., "Decreased plasma tryptophan associated with deep white matter lesions in elderly subjects", J NE NE PSY, 66(1), 1999, pp. 100-103

Abstract

The aim was to identify potentially treatable risk factors for cerebral white matter lesions often found on MRI in elderly persons. findings were assessed on 1.0 T MRI of 178 subjects Living in the community and aged 60 years or older. Participants underwent standardised evaluations including standard questionnaires, a physical and neurological examination, cognitive function tests, electrocardiogram, a complete blood chemistry panel, and plasmaamino acid measurements. Brain MRI infarcts, deep white matter lesions (DWMLs), and periventricular hyperintensities were found in 26%, 43%, and 29% of the 178 participants, respectively. Subjects with DWMLs were significantly older and had a higher frequency of hypertension, higher systolic blood pressure, and more brain infarcts, but lower plasma concentrations of tryptophan. In the multivariate model, greater age and lower plasma tryptophan concentrations were independently associated with DWMLs. Tryptophan concentrations were inversely related to DWML grading, whereas hypertension and brain infarction were more common in subjects with higher extents of DWMLs. The present study suggests that greater age and lower plasma tryptophan concentrations were important in producing DWMLs in elderly subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/20 alle ore 16:02:57