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Titolo:
Adding insult to injury: the prognostic value of early secondary insults for survival after traumatic brain injury
Autore:
Signorini, DF; Andrews, PJD; Jones, PA; Wardlaw, JM; Miller, JD;
Indirizzi:
Univ Edinburgh, Dept Clin Neurosci, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9YL Midlothian, Scotland Univ Edinburgh, Dept Anaesthet, Edinburgh EH8 9YL, Midlothian, Scotland Univ Edinburgh Edinburgh Midlothian Scotland EH8 9YL Midlothian, Scotland
Titolo Testata:
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
fascicolo: 1, volume: 66, anno: 1999,
pagine: 26 - 31
SICI:
0022-3050(199901)66:1<26:AITITP>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SEVERE HEAD-INJURY; INTENSIVE-CARE; INTRACRANIAL HYPERTENSION; MODELS; UNIT;
Keywords:
traumatic brain injury; prognosis; survival; secondary insults; adults;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Signorini, DF Univeweinburgh, Western Gen Hosp, Dept Clin Neurosci, Bramwell Dott Bldg,Cr Univ Edinburgh Bramwell Dott Bldg,Crewe Rd Edinburgh Midlothian Scotland EH4 2XU
Citazione:
D.F. Signorini et al., "Adding insult to injury: the prognostic value of early secondary insults for survival after traumatic brain injury", J NE NE PSY, 66(1), 1999, pp. 26-31

Abstract

Objectives-To assess the prognostic value of summary measures of secondaryphysiological insult in addition to baseline clinical variables for patients with traumatic brain injury. Methods-A series of 110 patients with traumatic brain injury had data on intracranial pressure (ICP), arterial blood pressure (ABP), cerebral perfusion pressure (CPP), arterial O-2 saturation (SaO(2)), temperature in degreesC (Temp), and heart rate in beats/min (HRT) monitored and recorded every minute. Secondary insults were defined according to the Edinburgh Universitysecondary insult grading system. The prognostic value of summary measures of these secondary insults was assessed by adding them to a prognostic model for survival at 1 year after controlling for baseline clinical variables using a previously validated model. Results-Of the eight secondary insults measured, only ICP added significantly to the prediction of survival in the first 72 hours after injury. The particular type of summary measure did not seem to influence the results. After the addition of ICP to the model, none of the other secondary insult measures could improve the predictive power of the model significantly. Conclusions-Early intracranial hypertension is confirmed as a sign of poorprognosis in patients with traumatic brain injury, even after controlling for baseline clinical variables. The value or otherwise of treating such secondary insults, however, can only be definitively established in the context of prospective randomised controlled trials. The specific pathophysiological evolution of secondary insults is still the subject of much research, and a clear understanding will be necessary before the development of specific treatments is feasible.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/10/20 alle ore 05:41:38