Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Noradrenergic neurotoxin suppresses gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in ovariectomized and steroid-treated rats
Autore:
Kang, SS; Son, GH; Seong, JY; Choi, D; Kwon, HB; Lee, CC; Kim, K;
Indirizzi:
Seoul Natl Univ, Coll Nat Sci, Dept Mol Biol, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 Biol, Seoul 151742, South Korea Seoulthatl Univ, Coll Nat Sci, Res Ctr Cell Differentiat, Seoul 151742, Sou Seoul Natl Univ Seoul South Korea 151742 Differentiat, Seoul 151742, Sou Chunnam Natl Univ, Coll Nat Sci, Dept Biol, Kwangju, South Korea Chunnam Natl Univ Kwangju South Korea , Dept Biol, Kwangju, South Korea Chunnam Natl Univ, Coll Nat Sci, Hormone Res Ctr, Kwangju, South Korea Chunnam Natl Univ Kwangju South Korea one Res Ctr, Kwangju, South Korea
Titolo Testata:
JOURNAL OF NEUROENDOCRINOLOGY
fascicolo: 12, volume: 10, anno: 1998,
pagine: 911 - 918
SICI:
0953-8194(199812)10:12<911:NNSGH(>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
MESSENGER-RNA LEVELS; PREPUBERTAL RATS; ESTROUS-CYCLE; PROGESTERONE; PITUITARY; HYPOTHALAMUS; ESTRADIOL; INVITRO; CELLS; NEUROTRANSMISSION;
Keywords:
noradrenaline; DSP4; GnRH; GnRH receptor; hypothalamus;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Kim, K Seoul Natl Univ, Coll Nat Sci, Dept Mol Biol, Seoul 151742, South Korea Seoul Natl Univ Seoul South Korea 151742 eoul 151742, South Korea
Citazione:
S.S. Kang et al., "Noradrenergic neurotoxin suppresses gonadotropin-releasing hormone (GnRH) and GnRH receptor gene expression in ovariectomized and steroid-treated rats", J NEUROENDO, 10(12), 1998, pp. 911-918

Abstract

The present study was designed to investigate whether noradrenergic neurotransmission regulates the gene expression of gonadotropin-releasing hormone(GnRH) in the preoptic area and GnRH receptor in the pituitary, To this end, N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP4, 50 mg/kg), an intraperitoneal (i.p.) injection of selective noradrenergic neurotoxin, was administered 1 h before progesterone (1 mg) treatment in ovariectomized and estradiol-treated prepubertal rats. Treatment with DSP4 effectively blocked theprogesterone-induced increase in hypothalamic noradrenaline content, but not dopamine content, indicating that DSP4 selectively inhibits noradrenergic neurotransmission, DSP4 significantly blocked progesterone-induced increase in serum luteinizing hormone (LH) concentrations as well as GnRH releasefrom hypothalamic fragments incubated in vitro. DSP4 concomitantly down-regulated GnRH mRNA levels in the preoptic area, as determined by competitivereverse transcription-polymerase chain reaction. DSP4 also clearly down-regulated progesterone-induced GnRH receptor mRNA levels in the pituitary, whereas it failed to alter LH beta mRNA levels. In summary, blockade of noradrenergic neurotransmission with DSP4 resulted in profound reductions of hypothalamic GnRH and pituitary GnRH receptor gene expression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:23:38