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Titolo:
Amantadine attenuates response alterations resulting from repetitive L-DOPA treatment in rats
Autore:
Karcz-Kubicha, M; Quack, G; Danysz, W;
Indirizzi:
Merz & Co, Dept Pharmacol Res, D-60318 Frankfurt, Germany Merz & Co Frankfurt Germany D-60318 acol Res, D-60318 Frankfurt, Germany
Titolo Testata:
JOURNAL OF NEURAL TRANSMISSION
fascicolo: 10-12, volume: 105, anno: 1998,
pagine: 1229 - 1236
SICI:
0300-9564(1998)105:10-12<1229:AARARF>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
NMDA RECEPTOR ANTAGONISTS; PARKINSONS-DISEASE; MOTOR FLUCTUATIONS; LEVODOPA; DYSKINESIAS; BLOCKADE;
Keywords:
amantadine; L-DOPA-response; fluctuations; rotations; rats;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Danysz, W Merzrt,Co, Dept Pharmacol Res, Eckenheimer Landstr 100-104, D-60318 Frankfu Merz & Co Eckenheimer Landstr 100-104 Frankfurt Germany D-60318
Citazione:
M. Karcz-Kubicha et al., "Amantadine attenuates response alterations resulting from repetitive L-DOPA treatment in rats", J NEURAL TR, 105(10-12), 1998, pp. 1229-1236

Abstract

It has been shown that NMDA receptor antagonists can inhibit both the development and expression of a decrease in the duration of L-DOPA action in rats rotating after unilateral lesion of the nigro-striatal dopaminergic system. Using this model we found that the low affinity NMDA receptor antagonist amantadine (50 mg/kg b.i.d.) attenuated both the expression and development of the shortening of duration of L-DOPA (25 mg/kg b.i.d.) action. Amantadine was most efficient when given both during the induction and expressionphase. However, an additional interaction experiment demonstrated that acutely given amantadine also prolongs the duration of L-DOPA-induced rotations. Hence, only the effect on development of shortening of L-DOPA action canbe regarded as specific for repetitive treatment mode. The data suggest that treatment with amantadine might have beneficial effects on response fluctuations produced by chronic L-DOPA treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 03:06:25