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Titolo:
The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins
Autore:
Mann, CJ; Anderson, TA; Read, J; Chester, SA; Harrison, GB; Kochl, S; Ritchie, PJ; Bradbury, P; Hussain, FS; Amey, J; Vanloo, B; Rosseneu, M; Infante, R; Hancock, JM; Levitt, DG; Banaszak, LJ; Scott, J; Shoulders, CC;
Indirizzi:
HammersmithEnglandImperial Coll Sch Med, MRC, Mol Med Grp, London W12 0NN,Hammersmith Hosp London England W12 0NN RC, Mol Med Grp, London W12 0NN, Hammersmith Hosp, Imperial Coll Sch Med, Gene & Genome Evolut Grp, Ctr Clin Hammersmith Hosp London England W12 0NN ne & Genome Evolut Grp, Ctr Clin Hammersmith Hosp, Imperial Coll Sch Med, Natl Heart & Lung Inst, London W12 Hammersmith Hosp London England W12 0NN tl Heart & Lung Inst, London W12 Univ Minnesota, Dept Biochem, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 iochem, Minneapolis, MN 55455 USA Inst Gerichtliche Med, A-6020 Innsbruck, Austria Inst Gerichtliche Med Innsbruck Austria A-6020 A-6020 Innsbruck, Austria State Univ Ghent, Dept Biochem, Lab Lipoprot Chem, B-9000 Ghent, Belgium State Univ Ghent Ghent Belgium B-9000 poprot Chem, B-9000 Ghent, Belgium INSERM, Ctr Rech, F-75571 Paris, France INSERM Paris France F-75571INSERM, Ctr Rech, F-75571 Paris, France
Titolo Testata:
JOURNAL OF MOLECULAR BIOLOGY
fascicolo: 1, volume: 285, anno: 1999,
pagine: 391 - 408
SICI:
0022-2836(19990108)285:1<391:TSOVPA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
TRIGLYCERIDE-TRANSFER-PROTEIN; B-CONTAINING LIPOPROTEINS; LOW-DENSITY-LIPOPROTEIN; BURIED SALT BRIDGES; APOLIPOPROTEIN-B; ENDOPLASMIC-RETICULUM; DISULFIDE-ISOMERASE; ABETALIPOPROTEINEMIA GENE; LDL-RECEPTOR; BINDING;
Keywords:
vitellogenin; apolipoprotein B; microsomal triglyceride transfer protein;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
71
Recensione:
Indirizzi per estratti:
Indirizzo: Scott, J HammersmithEnglandImperial Coll Sch Med, MRC, Mol Med Grp, LondonW12 0NN, Hammersmith Hosp London England W12 0NN ed Grp, London W12 0NN,
Citazione:
C.J. Mann et al., "The structure of vitellogenin provides a molecular model for the assembly and secretion of atherogenic lipoproteins", J MOL BIOL, 285(1), 1999, pp. 391-408

Abstract

The assembly of atherogenic lipoproteins requires the formation in the endoplasmic reticulum of a complex between apolipoprotein (apo)B, a microsomaltriglyceride transfer protein (MTP) and protein disulphide isomerase (PDI). Here we show by molecular modelling and mutagenesis that the globular amino-terminal regions of apoB and MTP are closely related in structure to theancient egg yolk storage protein, vitellogoenin (VTG). In the MTP complex,conserved structural motifs that form the reciprocal homodimerization interfaces in VTG are re-utilized by MTP to form a stable heterodimer with PDI,which anchors MTP at the site of apoB translocation, and to associate withapoB and initiate lipid transfer. The structural and functional evolution of the VTGs provides a unifying scheme for the Invertebrate origins of the major vertebrate lipid transport system. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 00:56:34