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Titolo:
Benign ethnic neutropenia: What is a normal absolute neutrophil count?
Autore:
Haddy, TB; Rana, SR; Castro, O;
Indirizzi:
Howard Univ, Coll Med, Sickle Cell Ctr, Washington, DC USA Howard Univ Washington DC USA l Med, Sickle Cell Ctr, Washington, DC USA Howard Univ, Coll Med, Dept Pediat & Child Hlth, Washington, DC USA HowardUniv Washington DC USA pt Pediat & Child Hlth, Washington, DC USA
Titolo Testata:
JOURNAL OF LABORATORY AND CLINICAL MEDICINE
fascicolo: 1, volume: 133, anno: 1999,
pagine: 15 - 22
SICI:
0022-2143(199901)133:1<15:BENWIA>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC IDIOPATHIC NEUTROPENIA; SEVERE CONGENITAL NEUTROPENIA; COLONY-STIMULATING FACTOR; AUTOIMMUNE NEUTROPENIA; GENETIC NEUTROPENIA; CRANIOSPINAL IRRADIATION; NEONATAL NEUTROPENIA; HEMATOLOGIC TOXICITY; CYCLIC NEUTROPENIA; PRIOR CHEMOTHERAPY;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
112
Recensione:
Indirizzi per estratti:
Indirizzo: Haddy, TB 10804 Whiterim Dr, Potomac, MD 20854 USA 10804 Whiterim Dr Potomac MD USA 20854 r, Potomac, MD 20854 USA
Citazione:
T.B. Haddy et al., "Benign ethnic neutropenia: What is a normal absolute neutrophil count?", J LA CL MED, 133(1), 1999, pp. 15-22

Abstract

Approximately 25% to 50% of persons of African descent and some ethnic groups in the Middle East have benign ethnic neutropenia, with low leukocyte and neutrophil counts. It is important to recognize the existence of this condition, the most common form of neutropenia throughout the world, and thusavoid both under-and overevaluation. Although there is no scientific basisfor an absolute neutrophil count of 1.5 x 10(9)/L to be considered minimal, counts below this level are empirically regarded as inadequate in personsof all ethnic groups who are above the age of 1 year,(1-4) Many individuals, however, maintain consistently low absolute neutrophil counts without evidence of increased susceptibility to infection or any other adverse effect. The important determination is not how many neutrophils are present in the peripheral blood, but whether the bone marrow is able to produce enough normally functioning cells when needed.(5-9) A description of benign ethnic neutropenia, as set forth in this review, suggests that the lower limit nowconsidered acceptable for the absolute neutrophil count should be readjusted downward for all ethnic groups.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 23:03:20