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Titolo:
The mast cell as site of tissue-type plasminogen activator expression and fibrinolysis
Autore:
Sillalber, C; Baghestanian, M; Bevec, D; Willheim, M; Agis, H; Kapiotis, S; Fureder, W; Bankl, HC; Kiener, HP; Speiser, W; Binder, BR; Lechner, K; Valent, P;
Indirizzi:
Univ Vienna, Dept Internal Med 1, Div Hematol & Hemostaseol, A-1090 Vienna, Univ Vienna Vienna Austria A-1090 Hematol & Hemostaseol, A-1090 Vienna, Univ Vienna, Dept Internal Med 3, Div Rheumatol, A-1090 Vienna, Austria Univ Vienna Vienna Austria A-1090 Div Rheumatol, A-1090 Vienna, Austria UnivAustria, Dept Vasc Biol & Thrombosis Res, Inst Physiol, A-1090 Vienna,Univ Vienna Vienna Austria A-1090 osis Res, Inst Physiol, A-1090 Vienna, Sandoz Res Inst, Vienna, Austria Sandoz Res Inst Vienna AustriaSandoz Res Inst, Vienna, Austria Univ Vienna, Inst Gen & Expt Pathol, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 & Expt Pathol, A-1010 Vienna, Austria Univ Vienna, Dept Lab Med, A-1010 Vienna, Austria Univ Vienna Vienna Austria A-1010 , Dept Lab Med, A-1010 Vienna, Austria Univ Vienna, Inst Clin Pathol, A-1010 Vienna, Austria Univ Vienna ViennaAustria A-1010 st Clin Pathol, A-1010 Vienna, Austria
Titolo Testata:
JOURNAL OF IMMUNOLOGY
fascicolo: 2, volume: 162, anno: 1999,
pagine: 1032 - 1041
SICI:
0022-1767(19990115)162:2<1032:TMCASO>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
SMOOTH-MUSCLE CELLS; IMMEDIATE HYPERSENSITIVITY REACTIONS; PROTEIN-C INHIBITOR; ENDOTHELIAL-CELLS; KIT-LIGAND; MYOCARDIAL-INFARCTION; AURICULAR THROMBOSIS; ESCHERICHIA-COLI; MOUSE SKIN; UROKINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
77
Recensione:
Indirizzi per estratti:
Indirizzo: Valent, P Univrtelnna, Dept Internal Med 1, Div Hematol & Hemostaseol, Waehringer Gue Univ Vienna Waehringer Guertel 18-20 Vienna Austria A-1090 Gue
Citazione:
C. Sillalber et al., "The mast cell as site of tissue-type plasminogen activator expression and fibrinolysis", J IMMUNOL, 162(2), 1999, pp. 1032-1041

Abstract

Recent data suggest that mast cells (MC) and their products (heparin, proteases) are involved in the regulation of coagulation and fibrino(geno)lysis. The key enzyme of fibrinolysis, plasmin, derives from its inactive progenitor, plasminogen, through catalytic action of plasminogen activators (PAs), In most cell systems, however, PAs are neutralized by plasminogen activator inhibitors (PAIs), We report that human tissue MC as well as the MC lineHMC-1 constitutively produce, express, and release tissue-type plasminogenactivator (tPA) without producing inhibitory PAIs. As assessed by Northernblotting, highly enriched lung MG (>98% pure) as web as HMC-1 expressed tPA mRNA, but did not express mRNA for PAI-1, PAI-2, or PAI-3, The tPA protein was detectable in RIG-conditioned medium by Western blotting and immunoassay, and the MC agonist stem cell factor (c-Kit ligand) was found to promote the release of tPA from MG, In addition, RIG-conditioned medium induced fibrin-independent plasmin generation as well as clot lysis in vitro. These observations raise the possibility that MC play an important role in endogenous fibrinolysis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/09/20 alle ore 09:45:26