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Titolo:
Coronal suture response to distraction osteogenesis in rabbits with delayed-onset craniosynostosis
Autore:
Losken, HW; Mooney, MP; Zoldos, J; Tschakaloff, A; Burrows, AM; Smith, TD; Cano, G; Arnott, R; Sherwood, C; Dechant, J; Cooper, GM; Kapucu, MR; Siegel, MI;
Indirizzi:
Univ Pittsburgh, Dept Anat & Histol, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 Histol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Plast & Reconstruct Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 ct Surg, Pittsburgh, PA 15261 USA Univ Pittsburgh, Cleft Palate Craniofacial Clin, Pittsburgh, PA 15261 USA Univ Pittsburgh Pittsburgh PA USA 15261 al Clin, Pittsburgh, PA 15261 USA Childrens Hosp, Dept Pediat Plast Surg, Pittsburgh, PA 15213 USA ChildrensHosp Pittsburgh PA USA 15213 ast Surg, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Anthropol, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 thropol, Pittsburgh, PA 15261 USA Univ Pittsburgh, Dept Orthodont, Pittsburgh, PA 15261 USA Univ PittsburghPittsburgh PA USA 15261 thodont, Pittsburgh, PA 15261 USA Slippery Rock Univ, Dept Phys Therapy, Slippery Rock, PA 16057 USA Slippery Rock Univ Slippery Rock PA USA 16057 Slippery Rock, PA 16057 USA Metamorph Surg Devices Inc, Harmarville, PA USA Metamorph Surg Devices Inc Harmarville PA USA s Inc, Harmarville, PA USA Carnegie Mellon Univ, Dept Bioengn, Pittsburgh, PA 15213 USA Carnegie Mellon Univ Pittsburgh PA USA 15213 gn, Pittsburgh, PA 15213 USA Univ Pittsburgh, Dept Anthropol & Orthodont, Pittsburgh, PA USA Univ Pittsburgh Pittsburgh PA USA hropol & Orthodont, Pittsburgh, PA USA
Titolo Testata:
JOURNAL OF CRANIOFACIAL SURGERY
fascicolo: 1, volume: 10, anno: 1999,
pagine: 27 - 37
SICI:
1049-2275(199901)10:1<27:CSRTDO>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
MANDIBULAR DISTRACTION; CALLUS DISTRACTION; CRANIAL VAULT; GROWTH; SYNOSTOSIS; EXPANSION; OSTEOTOMIES; BIOLOGY; SKULL; ADVANCEMENT;
Keywords:
craniosynostosis; rabbits; distraction; suture; bone; cytokines;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Mooney, MP UnivAPittsburgh, Dept Anat & Histol, 619 Salk Hall, Pittsburgh,PA 15261 US Univ Pittsburgh 619 Salk Hall Pittsburgh PA USA 15261 15261 US
Citazione:
H.W. Losken et al., "Coronal suture response to distraction osteogenesis in rabbits with delayed-onset craniosynostosis", J CRANIOF S, 10(1), 1999, pp. 27-37

Abstract

Recent studies have identified a subpopulation of persons with craniosynostosis who exhibit progressive or delayed-onset synostosis and mild cranial vault deformities. These persons may be good candidates for nonextirpation distraction osteogenesis. The present studies were designed to determine force-displacement parameters and assess the effects of distraction osteogenesis on coronal suture growth and morphologic characteristics in a rabbit model with congenital, delayed-onset craniosynostosis. Data were collected from a total of 178 rabbits: 71 normal controls; 16 normal controls with distraction; 72 with delayed-onset coronal suture synostosis; and 19 with delayed-onset coronal suture synostosis and distraction. At 10 days of age, all rabbits had amalgam markers placed on both sides of the coronal suture. In the force-displacement study, force-displacement distracters were placed across the coronal suture and distracted acutely for 1.0 mm at 42 days of age. Force-displacement curves for the coronal suture were best described by athird-order polynomial regression equation for both normal and synostosed groups. Significant differences (P < 0.05) were found in the mean force necessary to distract a normal suture 1 mm in distance (13.72 kg) compared with a suture with delayed-onset synostosis (48.39 kg). A significant (P < 0.05) relationship was also found between the extent of synostosis and the distractive force in rabbits with delayed-onset synostosis. In the distractionstudy, internal distracters were fixed across the coronal suture at 25 days of age and percutaneously and intermittently activated at an average of 0.11 mm/day for 42 days (4.54 mm total). Serial radiographs were taken at 10, 25, 42, and 84 days of age. Results revealed that rabbits with delayed-onset synostosis and distraction had significantly (P < 0.01) more coronal suture growth rates compared with rabbits with delayed-onset synostosis and no distraction. Coronal sutures were harvested at 84 days of age for qualitative histologic examination. Normal, distracted coronal sutures showed widened sutural ligaments and thin, active osteogenic fronts. In contrast, distracted coronal sutures from rabbits with delayed-onset synostosis showed narrowed sutural ligaments, thickened and blunt osteogenic fronts, and increased collagen and bony matrix deposition compared with controls. Results suggest that distraction osteogenesis without corticotomy may be a treatment alternative in persons with progressive, delayed-onset synostosis. However, these preliminary data also suggest that distractive forces may accelerate or stimulate osteogenesis differentially in persons with craniosynostosis, possibly through an underlying genetic disorder of bone and cytokine regulation. These differential osteogenic responses to distraction, if validated clinically, will need to be taken into account when planning distraction rate and rhythm protocols for patients with craniosynostosis.

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Documento generato il 12/07/20 alle ore 06:48:54