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Titolo:
Regulation of intracellular membrane interactions: Recent progress in the field of neurotransmitter release
Autore:
Burger, MM; Schafer, T;
Indirizzi:
Friedrich Miescher Inst, CH-4002 Basel, Switzerland Friedrich Miescher Inst Basel Switzerland CH-4002 002 Basel, Switzerland
Titolo Testata:
JOURNAL OF CELLULAR BIOCHEMISTRY
, , anno: 1998, supplemento:, 30-31
pagine: 103 - 110
SICI:
0730-2312(1998):<103:ROIMIR>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA2+-ACTIVATED SECRETION; CLOSTRIDIAL NEUROTOXINS; PHOSPHATIDIC-ACID; CHROMAFFIN CELLS; YEAST VACUOLES; FUSION; EXOCYTOSIS; PROTEIN; DOCKING; VESICLES;
Keywords:
secretion; SNARE hypothesis; priming; fusion competence; phosphoinositides;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Burger, MM Friedrich Miescher Inst, POB 2543, CH-4002 Basel, Switzerland Friedrich Miescher Inst POB 2543 Basel Switzerland CH-4002 and
Citazione:
M.M. Burger e T. Schafer, "Regulation of intracellular membrane interactions: Recent progress in the field of neurotransmitter release", J CELL BIOC, 1998, pp. 103-110

Abstract

Maintenance of compartmental independence and diversity is part of the blueprint of the eukaryotic cell. The molecular composition of every organellemembrane is custom tailored to fulfill its unique tasks. it is retained bystrict sorting and directional transport of newly synthesized cellular components by the use of specific transport vesicles. Temporally and spatiallycontrolled membrane fission and fusion steps thus represent the basic process for delivery of both, membrane-bound and soluble components to their appropriate destination. This process is fundamental to cell growth, organelle inheritance during cell division, uptake and intracellular transport of membrane-bound and soluble molecules, and neuronal communication. The tatterprocess has become one of the best studied examples in terms of regulatorymechanisms of membrane interactions. It has been dissected into the stagesof transmitter vesicle docking, priming, and fusion: Specificity of membrane interactions depends on interactions between sets of organelle-specific membrane proteins. Priming of the secretory apparatus is an ATP-dependent process involving proteins and membrane phospholipids. Release of vesicle content is triggered by a rise in intracellular free Ca2+ levels that relieves a block previously established between the membranes poised to fuse. Neurotransmitter release is a paradigm of highly regulated intracellular membrane interaction and molecular mechanisms for this phenomenon begin to be delineated.. Cell. Biochem. Suppls. 30/31:103-110, 1998. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 13:33:42