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Titolo:
Effect of policosanol on intimal thickening in rabbit cuffed carotid artery
Autore:
Noa, M; Mas, R; Mesa, R;
Indirizzi:
Natl Ctr Sci Res, Ctr Natl Prod, Lab Histol, Havana, Cuba Natl Ctr Sci Res Havana Cuba s, Ctr Natl Prod, Lab Histol, Havana, Cuba
Titolo Testata:
INTERNATIONAL JOURNAL OF CARDIOLOGY
fascicolo: 2, volume: 67, anno: 1998,
pagine: 125 - 132
SICI:
0167-5273(199812)67:2<125:EOPOIT>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACCELERATED ATHEROSCLEROSIS; II HYPERCHOLESTEROLEMIA; NEOINTIMA FORMATION; CELL-PROLIFERATION; CYCLIN PCNA; RATS; PROSTACYCLIN; ENDOTHELIUM; METABOLISM; APOPTOSIS;
Keywords:
policosanol; smooth muscle cell proliferation;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Noa, M Natlna,r Sci Res, Ctr Natl Prod, Lab Histol, 25 Ave & 158 St,POB 6990, Hava Natl Ctr Sci Res 25 Ave & 158 St,POB 6990 Havana Cuba 6990, Hava
Citazione:
M. Noa et al., "Effect of policosanol on intimal thickening in rabbit cuffed carotid artery", INT J CARD, 67(2), 1998, pp. 125-132

Abstract

We studied the effect of policosanol on smooth muscle cell proliferation in the cuffed carotid artery of the rabbit. Policosanol is a mixture of higher aliphatic primary alcohols isolated from sugar cane wax, with cholesterol lowering effects proved in experimental models and patients with type II hypercholesterolemia. It acts by inhibiting cholesterol biosynthesis. The positioning of a nonocclusive silicone collar around the rabbit carotid artery results in the formation of a neointima. We wished to determine whether policosanol orally administered prevented intimal thickening. Collars were placed around the left carotid for 15 days. The contralateral artery was sham operated. We included three experimental groups: a control received vehicle and two others policosanol at 5 and 25 mg Kg until sacrificed. Samples of arteries were examined by light and electron microscopy. To evaluate intimal thickening the cross-sectional area of intima and media were measured. Neointima was significantly reduced in policosanol-treated animals compared with controls. The smooth muscle cell proliferation was studied by the immunohistochemical detection of proliferating cell nuclear antigen and a significant reduction was observed in policosanol treated rabbits. It is concluded that policosanol has a protective effect on the neointima formation inthis experimental model. (C) 1998 Elsevier Science Ireland Ltd. All rightsreserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/10/20 alle ore 09:57:19