Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human
Autore:
Jiang, JC; Kirchman, PA; Zagulski, M; Hunt, J; Jazwinski, SM;
Indirizzi:
Louisiana12tate Univ, Med Ctr, Dept Biochem & Mol Biol, New Orleans, LA 701 Louisiana State Univ New Orleans LA USA 70112 l Biol, New Orleans, LA 701
Titolo Testata:
GENOME RESEARCH
fascicolo: 12, volume: 8, anno: 1998,
pagine: 1259 - 1272
SICI:
1054-9803(199812)8:12<1259:HOTYLG>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-LIVED STRAIN; DROSOPHILA-MELANOGASTER; SACCHAROMYCES-CEREVISIAE; POSTPONED SENESCENCE; LIFE-SPAN; TRANSCRIPTION FACTOR; HUMAN-DISEASE; UV STRESS; RESISTANCE; SEQUENCES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
58
Recensione:
Indirizzi per estratti:
Indirizzo: Jazwinski, SM Louisiana12tate Univ, Med Ctr, Dept Biochem & Mol Biol, New Orleans, LA 701 Louisiana State Univ New Orleans LA USA 70112 leans, LA 701
Citazione:
J.C. Jiang et al., "Homologs of the yeast longevity gene LAG1 in Caenorhabditis elegans and human", GENOME RES, 8(12), 1998, pp. 1259-1272

Abstract

LAG1 is a longevity gene, the first such gene to be identified and cloned from the yeast Saccharomyces cerevisiae. A close homolog of this gene, which we call LAC1, has been found in the yeast genome. We have cloned the human homolog of LAG1 with the ultimate,ooal of examining its possible functionin human aging. In the process, we have also cloned a homolog from the nematode worm Caenorhabditis elegans. Both of these homologs, LAG1Hs and LAG1Ce-1 functionally complemented the lethality of a lag1 Delta lac1 Delta double deletion, despite low overall sequence similarity to the yeast proteins. The proteins shared a short sequence, the Lag1 motif, and a similar transmembrane domain profile. Another, more distant human homolog, TRAM, which lacks this motif, did not complement. LAG1Hs also restored the life span of the double deletion, demonstrating that it functions in establishing the longevity phenotype in yeast. LAG1Hs mapped to 19p12, and it was expressed in only three tissues: brain, skeletal muscle, and testis. This gene possessesa trinucleotide (CTG) repeat within exon 1. This and its expression profile raise the possibility that it may be involved in neurodegenerative disease. This possibility suggests at least one way in which LAG1Hs might be involved in human aging.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:43:55