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Titolo:
Nitric oxide is required for expression of LTP that is induced by stimulation phase-locked with theta rhythm
Autore:
Holscher, C;
Indirizzi:
Univ Dublin Trinity Coll, Dept Physiol, Dublin 2, Ireland Univ Dublin Trinity Coll Dublin Ireland 2 ept Physiol, Dublin 2, Ireland
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 1, volume: 11, anno: 1999,
pagine: 335 - 343
SICI:
0953-816X(199901)11:1<335:NOIRFE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; 1-(2-TRIFLUOROMETHYLPHENYL) IMIDAZOLE TRIM; CA1 IN-VIVO; SYNTHASE INHIBITOR; SYNAPTIC PLASTICITY; AREA CA1; 7-NITRO INDAZOLE; MEMORY FORMATION; RAT HIPPOCAMPUS; NERVOUS-SYSTEM;
Keywords:
awake rats; hippocampus; long-term potentiation (LTP); nitric oxide; theta rhythm;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
55
Recensione:
Indirizzi per estratti:
Indirizzo: Holscher, C UnivdDublin Trinity Coll, Dept Physiol, Earlsfort Terrace, Dublin 2, Irelan Univ Dublin Trinity Coll Earlsfort Terrace Dublin Ireland 2 n
Citazione:
C. Holscher, "Nitric oxide is required for expression of LTP that is induced by stimulation phase-locked with theta rhythm", EUR J NEURO, 11(1), 1999, pp. 335-343

Abstract

Long-term potentiation (LTP) can be induced by giving only one burst (fivestimuli at 200 Hz) on the positive phase of sensory-induced theta rhythm in awake or anaesthetized rats, a stimulation protocol that mimics naturallyoccurring neuronal activity. Nitric oxide has been discussed as an important neuronal messenger in the induction of LTP. However, experiments testinginhibitors of nitric oxide synthase (NOS) in vitro produced contradictory results. The non-specific NOS inhibitor Nitro-L-arginine (L-NARG) impaired LTP induced by high-frequency stimulation (HFS) [from 155 +/- 7% to 122 +/-8%), but completely blocked theta-dependent LTP induction (161 +/- 8% to 102 +/- 5%). NOS inhibitors, e.g. 7-nitro indazole (7-NI) or 1-(2-trifluoromethylphenyl) imidazole (TRIM) that are more selective for neuronal NOS and affect blood pressure less also impaired HFS-induced LTP (186 +/- 11% to 135 +/- 9% for TRIM) but completely blocked theta-dependent LTP (154 +/- 7 to91 +/- 8). L-Arginine reversed the effects of the NOS inhibitors tested. Therefore, NO appears to be a modulator that is important for synaptic plasticity in this more physiological stimulation technique in vivo. NO is not released in slice preparations in sufficient quantities or at the right timing. Instead, the unphysiologically strong HFS protocol appears to induce anNO-independent type of LTP in some cases.

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Documento generato il 29/03/20 alle ore 15:10:43