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Titolo:
Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?
Autore:
Dimmeler, S; Hermann, C; Zeiher, AM;
Indirizzi:
Univrmanykfurt, Dept Internal Med 4, Div Mol Cardiol, D-60590 Frankfurt, Ge Univ Frankfurt Frankfurt Germany D-60590 Cardiol, D-60590 Frankfurt, Ge
Titolo Testata:
EUROPEAN CYTOKINE NETWORK
fascicolo: 4, volume: 9, anno: 1998,
pagine: 697 - 698
SICI:
1148-5493(199812)9:4<697:AOECCT>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; INHIBITION; PROTEASES; DEATH;
Keywords:
endothelial cells; nitric oxide; oxidants; anti-oxidants; shear stress; caspases; Bcl-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
13
Recensione:
Indirizzi per estratti:
Indirizzo: Dimmeler, S UnivD-60590urt, Dept Internal Med 4, Div Mol Cardiol, Theodor Stern Kai 7, Univ Frankfurt Theodor Stern Kai 7 Frankfurt Germany D-60590
Citazione:
S. Dimmeler et al., "Apoptosis of endothelial cells. Contribution to the pathophysiology of atherosclerosis?", EUR CYTOKIN, 9(4), 1998, pp. 697-698

Abstract

Endothelial cell injury is a key event in the pathogenesis of atherosclerosis, Importantly, endothelial cells in lesion-prone regions, where atherosclerotic lesions preferentially develop, are characterised by increased endothelial cell turn-over rates suggesting a mechanistic link between endothelial cell turn-over with preceding cell death and the susceptibility to atherosclerotic plaque development. The activation of the cellular suicide pathway leading to apoptosis of the endothelial cell mag be an initial step in the development of atherosclerotic lesions. This hypothesis is supported bythe finding that proatherosclerotic factors such as angiotensin II, oxidized low density lipoprotein, reactive oxygen species, glucose and inflammatory cytokines have all been shown to induce apoptosis of endothelial cells. In contrast, the known atheroprotective factors, such as oestrogen, nitric oxide or anti-oxidants, prevented endothelial cell apoptosis, Furthermore, laminar flow, which seems to be one of the most potent endogenous anti-atherosclerotic factor as illustrated by the focal nature of atherosclerotic lesion development in areas with turbulent or low blood flow protects endothelial cell from apoptotic cell death. The present article summarizes the effects of pro and anti-atherosclerotic factors on endothelial cell apoptosis and provides insights into the underlying signalling events.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 20:23:59