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Titolo:
Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections
Autore:
Bagnard, D; Lohrum, M; Uzeil, D; Puschel, AW; Bolz, J;
Indirizzi:
INSERM, U371, Cerveau & Vis, F-69500 Bron, France INSERM Bron France F-69500 RM, U371, Cerveau & Vis, F-69500 Bron, France Max Planck Inst Hirnforsch, Neurochem Abt, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany UnivoFed Rio de Janeiro, CCS BLF, ICB, Lab Neuroplaticidade, BR-21941590 Ri Univ Fed Rio de Janeiro Rio De Janeiro RJ Brazil BR-21941590 BC1941590 Ri
Titolo Testata:
DEVELOPMENT
fascicolo: 24, volume: 125, anno: 1998,
pagine: 5043 - 5053
SICI:
0950-1991(199812)125:24<5043:SAAAAR>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERIPHERAL-NERVE PROJECTION; GROWTH-PROMOTING MOLECULES; RAT CEREBRAL-CORTEX; SPINAL-CORD; MURINE SEMAPHORIN; AXON GUIDANCE; EXPRESSION; NEUROPILIN; FAMILY; RECEPTOR;
Keywords:
semaphorins; cortex; wiring molecules; axonal guidance;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Bolz, J Univ Jena, Inst Allgemeine Zool, Erbertstr 1, D-07743 Jena, Germany Univ Jena Erbertstr 1 Jena Germany D-07743 D-07743 Jena, Germany
Citazione:
D. Bagnard et al., "Semaphorins act as attractive and repulsive guidance signals during the development of cortical projections", DEVELOPMENT, 125(24), 1998, pp. 5043-5053

Abstract

Members of the semaphorin family have been implicated in mediating axonal guidance in the nervous system by their ability to collapse growth cones and to function as chemorepellents. The present findings show that recombinant Semaphorin D has similar effects on cortical axons and, in addition, inhibits axonal branching, In contrast, semaphorin E acts as an attractive guidance signal for cortical axons, Attractive effects were only observed when growth cones encountered increasing concentrations or a patterned distribution of Semaphorin E, but not when they are exposed to uniform concentrations of this molecule. Specific binding sites for Semaphorin D and Semaphorin E were present on cortical fibers both in vitro and in vivo at the time when corticofugal projections are established. In situ hybridization analysis revealed that the population of cortical neurons used in our experiments express neuropilin-1 and neuropilin-2, which are essential components of receptors for the class III semaphorins, Moreover, semD mRNA was detected in the ventricular zone of the neocortex whereas semE mRNA was restricted to thesubventricular zone. Taken together, these results indicate that semaphorins are bifunctional molecules whose effects depend on their spatial distribution. The coordinated expression of different semaphorins, together with their specific activities on cortical axons, suggests that multiple guidancesignals contribute to the formation of precise corticofugal pathways.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 02:05:42