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Titolo:
Immunoregulatory networks in asthma
Autore:
Le Gros, G; Erb, K; Harris, N; Holloway, J; McCoy, K; Ronchese, F;
Indirizzi:
Malaghan Inst Med Res, Wellington, New Zealand Malaghan Inst Med Res Wellington New Zealand s, Wellington, New Zealand
Titolo Testata:
CLINICAL AND EXPERIMENTAL ALLERGY
, volume: 28, anno: 1998, supplemento:, 5
pagine: 92 - 96
SICI:
0954-7894(199811)28:<92:INIA>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-LYMPHOCYTES; TH2 CELLS; COSTIMULATION; EXPRESSION; INDUCTION; MOLECULES; CTLA-4; CD80;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
19
Recensione:
Indirizzi per estratti:
Indirizzo: Le Gros, G Malaghan Inst Med Res, POB 7060, Wellington, New Zealand Malaghan Inst Med Res POB 7060 Wellington New Zealand Zealand
Citazione:
G. Le Gros et al., "Immunoregulatory networks in asthma", CLIN EXP AL, 28, 1998, pp. 92-96

Abstract

It is now well established that a subset of T-cell-derived cytokines (termed Th2 cytokines) programme the timing and characteristics of atopic airwaydisease including mast-cell sensitization, eosinophil and lymphocyte infiltration and recently mucus secretion. To date, attempts to devise ways to selectively limit the activities of Th2 cytokine-producing cells have been frustrated. However, the recent identification of the molecules which directthe activation and maturation of T cells has led to some successful attempts to block the activities of Th2 cells in models of atopic airway inflammation. Some of the agents with the most potential include antagonists of theT-cell costimulatory molecule CD28, local stimulators of the Th1 subset ofcytokines such as the BCG vaccine and potentially, antagonists of the eotaxin chemokine receptor and agonists of the T-cell costimulatory molecule CTLA-4. Not only do such agonists and antagonists represent potential new therapies, they could represent a rich hunting ground for those who aim to determine the ways in which atopic airway disease can be diagnosed and understood.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 13:32:14